南京地区34家医院2012～2014年常用喹诺酮类药利用分析

Application Analysis of Quinolones in 34 Hospitals in Nanjing during the Year of 2012-2014

目的：评价南京地区喹诺酮类药的利用情况。方法：对南京地区34家医院2012～2014年喹诺酮类药的销售金额、用药频度（DDDs）和限定日费用（DDC）等进行回顾性统计分析。结果：该地区医院2012～2014年喹诺酮类销售金额和DDDs呈小幅增长趋势，复合年均增长率（CAGR）分别为3．35％、0．09％。3年中，莫西沙星的DDDs和销售金额均排名第一，且逐年上升。左氧氟沙星销售金额小幅下降，但DDDs小幅增长。洛关沙星DDDs和销售金额下降趋势较明显，2013年淘汰3种喹诺酮类药（依诺沙星、氟罗沙星、司帕沙星）。结论：该地区医院喹诺酮类药的应用呈上升趋势，但为防止临床滥用以延缓细菌耐药性的产生，建议严格控制喹诺酮类药的应用，以确保临床用药安全、有效和经济。

Objective： To evaluate the utilization of quinolones in 34 hospitals in Nanjing. Methods： By a retrospective study, quinolones used in Nanjing during the year of 2012-2014 were analyzed statistically in respect of the consumption sum, DDDs and DDC etc. Results： During the 3 years, the growth of consumption sum and DDDs of quinolones was small with compound annual growth rate （CAGR） of 3.35% and 0.09% ,respectively. The consumption sum and DDDs of moxifloxacin was ranked No. 1 during the 3 years, and increased year by year. The consumption sum of levofloxaein was decreased slightly,while the DDDs was increased. The consump- tion sum and DDDs of lomefloxacin were decreased obviously. In 2013 ,three kinds of quinolones （enoxacin, fleroxocin and sparfloxaein） were eliminated. Conclusion： As the application of quinolones in Nanjing is increased, the strict application control of quinolones is recommended to delay the generation of bacterial resistance and ensure the safe, effective and economical medication.