盐酸舍曲林联合心理辅导治疗早泄及对患者性生活满意度改善效果的回顾性研究

Retrospective Study on Sertraline Combined with Psychological Service in the Treatment of Patients with Premature Ejaculation and Its Effect on Patient Sexual Satisfaction

目的:观察盐酸舍曲林治疗早泄及对患者性生活满意度改善的效果。方法:采用回顾性研究方法,280例早泄患者根据治疗方法不同分为观察组和对照组。对照组140例采用采用常规心理治疗;观察组在对照组基础上加用盐酸舍曲林胶囊50 g·d^(-1),po。比较治疗1个月后两组患者的射精潜伏期、中国早泄患者性功能评价表(CIPE)评分、汉密尔顿抑郁量表(HAMD)评分、国际勃起功能评分表(IIEF-5)评分,以及两组患者和配偶的性生活满意度、药品不良反应发生情况等。结果:治疗后,两组患者射精潜伏期、CIPE评分、HAMD评分、IIEF-5评分等各项指标均较治疗前明显改善(P<0.05),且观察组患者明显优于对照组(P<0.05)。观察组患者及配偶的总满意率明显高于对照组(P<0.05)。观察组患者药品不良反应发生率明显高于对照组(P<0.05),但均较轻微可耐受。结论:在传统的心理辅导行为基础上给予盐酸舍曲林治疗早泄,能显著改善患者射精潜伏期、CIPE评分、HAMD评分、IIEF-5评分等各项指标,提高患者及配偶的满意度,不良反应症状较轻微,值得临床推广。

Objective： To observe the effect of sertraline in the treatment of premature ejaculation and on the sexual satisfaction of patients. Methods： Totally 280 cases of urological patients were studied retrospectively. According to the treatment regimen, the patients were divided into the observation group and the control group. The 140 patients in the observation group were additionally treated with sertraline 50 mg · d- 1 ,po, and those in the control group was treated with conventional routine behavioral counseling. After the one-month treatment, the ejaculatory latency, CIPE, HAMD, IIEF-5 score, spouse sexual satisfaction and the incidence of adverse reactions in the two groups were analyzed. Results： After the treatment, the ejaculation latency in the two groups was significantly improved when compared with that before the treatment, and the difference was statistically significant （ P 〈 0.05 ）, and the ejaculatory latency in the observation group was significantly higher （ P 〈 0.05 ）. CIPE score in the two groups after the treatment was significantly improved when compared with that before the treatment, and the difference was statistically significant（ P 〈 0.05 ）, and that in the observation group was significantly higher （P 〈 0.05 ）. HAMD and IIEF-5 score in the two groups after the treatment was obviously improved, and the difference was statistically significant （P 〈 0.05 ）, and those in the observation group were superior to those in the control group, and the difference was statistically significant （P 〈 0.05）. The overall satisfaction rate of spouse in the observation group was significantly higher （P 〈 0.05） than that in the control group, and the difference was statistically significant （ P 〈 0.05 ）. The adverse reactions in the observation group were significantly fewer than those in the control group, and the difference was statistically significant （P 〈 0.05）. Conclusion： Sertraline combined with traditional counseling behavioral therapy can significantly improve the ejaculatory latency, CIPE, HAMD, IIEF-5 score and spouse sexual satisfaction with lower incidence of adverse reactions in the treatment of premature ejaculation, which should be promoted in clinics.