电子显微镜在肿瘤诊断上的应用——1000例光镜及电镜观察

APPLICATION OF ELECTRON MICROSCOPY TO TUMOR DIAGNOSIS——OBSERVATION OF 1000 CASES WITH BOTH LIGHT AND ELECTRON MICROSCOPY

作者用光镜及电镜对比观察了1000例人体肿瘤,结果如下:①电镜与光镜诊断完全相符者占93％;②电镜观察改变了原光镜诊断,或光镜未能确诊,通过电镜观察才确定诊断者,占4％;③电镜诊断与光镜诊断基本相同,但有补充或发展,占3％;④电镜观察仍未能确诊者,占1％。对电镜在肿瘤诊断中的意义、范围以及几类常见恶性肿瘤的电镜诊断进行了讨论。

We observed 1000 cases human tumorsby electron microscope, as compared with bylight microscope. Results were classified intofour groups: First, the diagnosis by bothlight microscope and electron microscopewere the same in 92 per cent of total cases.Second, diagnosis by light microscope wascompletely changed by the use of electronmicroscope, and the correct diagnosis wasdetermined only by electron microscope in 4percent when light microscope failed. Third,although major diagnosis of some tumorsby both light and electron microscope wasthe same, by electron microscope, the dia-gnosis was extended and supplemented in 3per cent. Finally, diagnosis was still unclearin 1 per cent. We think that ultrastructuralevaluation contributes to diagnosis in 7 percent of all the cases. Electron microscopeplays a very important role in the differen-tial diagnosis of tumors, especially, smallcell malignant tumors, and pleomorphic ma-lignant tumors, and also in determinationof two-directional or multi-directional diffe-rentiation of some tumors.