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p53抗体与恶性肿瘤 被引量：1

p53 Antibody and Malignant Tumor
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摘要 p53基因是人类肿瘤中突变频率最高的抑癌基因,几乎发生于所有的恶性肿瘤.突变基因编码的p53蛋白释放入血,可诱发机体自身免疫应答,产生p53自身抗体.在肿瘤病人和高危人群中检测血清p53抗体可以反映早期p53基因突变,作为一种新的肿瘤生物学指标,p53抗体有望在恶性肿瘤的早期诊断、治疗、预后、监测、复发等方面发挥重要作用. p53 gene, the highest mutational frequency in human tumor, almost occurs in all of malignant tumors. The mutational gene code p53 protein entry in blood, which can induce autoimmunity of organism and produce p53 auto antibodies in patients. The serum p53 antibody detected in patients with tumor and high risk group can reflect the early mutation of p53 gene. As a new tumor biology index, p53 antibody can play the important role in the early diagnosis, treatment, prognosis, recurrence of malignant tumor.
作者 曾常茜 王振明
机构地区 北华大学医学院
出处 《北华大学学报（自然科学版）》 CAS 2002年第4期300-303,共4页 Journal of Beihua University（Natural Science）
基金 吉林省卫生厅科学基金资助项目(1998-9)
关键词 P53基因 P53抗体 恶性肿瘤 抑癌基因 基因突变 肿瘤发生 肿瘤诊断 p53 gene p53 antibody Malignant tumor
分类号 R730.231 [医药卫生—肿瘤] R392.11 [医药卫生—免疫学]
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参考文献17

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同被引文献17

  • 1BdIint EE, Vousden KH. Activation and activities of the p53 turnout suppressor protein[ J]. Br J Cancer, 2001,85(12) :1813-1823.
  • 2MukhopadhyayUK, Mak AS. 1)53 : is the guardian of the genome also a suppressor of cell invasion? [ J]. Cell Cycle,2009,8(16) :2481.
  • 3Teodoro JG, Evans SK, Green MR. Inhibition of tumor angiogene- sis by p53: a new role for the guardian of the genome[ J]. J Mol Med (B), 2OO7,85(1D :1175-1186.
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  • 6Hainaut P, Hollstein M. p.53 and human cancer: the fn'st ten thou- sand mutations[ J]. Adv Cancer Res, 2000,77:81-137.
  • 7Burg SH van der, de Cock K, Mennon AG, et al. Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibod- ies in patients with resectod primary colorectal cancer[J]. Eur J Irnmu- nol,2001 ,31(1) :146-55.
  • 8Crawford LV, Pim DC, Bulbrook RD. Detection of antibodies a- gainst the cellular protein p53 in sera from patients with breast cancer [J]. Int J Cancer, 1982,30(4) :403-408.
  • 9Soussi T. p53 Antibodies in the sera of patients with various types of cancer: a review[J]. Cancer Res, 2000 ,60(7) :1777-1788.
  • 10Regele S, Koldberger P, Vogl FD, et al. Serum p53 autoantibod- ies in patients with minimal lesions of ductal carcinoma in situ of the breast[J]. Br J Cancer,1999,81(4) :702-704.

引证文献1

北华大学学报（自然科学版）
2002年 第4期

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