抗胸腺细胞血清的研究

A STUDY OF ANTITHYMOCYTE SERA

本文研究了家兔抗小白鼠胸腺细胞血清的体内外活性。在体外有凝集胸腺细胞的作用;在体内对淋巴器官有明显的免疫抑制作用,包括降低周围血液白血球,胸腺的萎缩及胸腺细胞的排空;脾,淋巴结胸腺依赖区淋巴细胞选择性减少。 进一步证实ATS在移植中的作用。ATS方法可常规应用于细胞株致癌性的鉴定。由于ATS方法简单,重复性强,诱发肿瘤时间短,值得推广。

In this paper the activities of rabbits anti-mice thymocyte sera both in vitro and in vivo are reported, ATS is shown that there is an effect of agglutinating thymus celIs in vitro and expticit immunosuppressions on lymphoid organs in vivo, including leukocytopenia in peripheral blood, atrophy and cellular deplation in thymus and decrease of the number of lymphoid cells selectively on thymus dependent areas in spleen and lymph nodes.The role of ATS in transplantation is further demonstrated. ATS method can be used routinely in the identification of carcinogenlcity of cultured cell lines. Due to its simplicity, repeat well and a short time lag of inducing tumour, ATS merits extensive application.