摘要
本组7例急性T细胞免疫功能缺陷病人,经用小牛FHF_(?)后,临床症状及实验室检查初步说明,该制品具有一定的改善患者细胞免疫功能状态和抗病毒、霉菌感染的作用。本文所采用的小牛THF_(?)是在Goldstein氏的提取方法基础上进行了改进,分子量在15,000以下,免疫电泳分析显示没有牛血清白蛋白的大分子物质,脐带血玫瑰花结测定存在活性。由于本组病例尚少,还有待进一步探讨。
Calf thymosin fration 5 (THF 5), prepared by modified Goldstein method, was given to 7 patients with acute acquired immunodeficiency diseases, including 1 fulminant Japanese B encephalitis associated with respiratory failure: 1 fulminant infectious hepatitis associated with hepatic coma; 1 chronic active hepatitis associated with peritonitis; 1 systemic lupus erythematosus associated with herpes zoster: 1 severe heat-exhaustion associated with deep coma, bacteriemia, and decubitus ulcer: 1 chronic granulocytic leukemia associated with fungal pneumonia: and 1 acute lymphocytic leukemia associated with pseudomonas aerogenosa infection.The molecular weight of THF 5 is less than 15000. Electrophoretic analysis revealed no bovine serum albumin. Further studies on this substance which is promising in treating immunodeficiency diseases are necessary before it can be recommended in clinical practice.
出处
《北京医学》
CAS
1979年第4期219-222,共4页
Beijing Medical Journal
