β_2-微球蛋白测定监测肺心病患者的肾功能

RENAL FUNCTION IN CHRONIC COR PULMONALE MONITORED WITH β_2-MICROGLOBULIN

作者采用放射免疫法,测定26例正常健康人和40例慢性肺源性心脏病(肺心病)患者(52例次)的血清和尿中的β_2-微球蛋白(β_2-microglobulin,β_2-MG)。结果表明:肺心病患者血清和尿中的β_2-MG(3.86±1.58mg/L和0.66±0.34mg/L)与正常健康人(2.01±0.47mg/L和0.10±0.08mg/L)有极显著性差异(P<0.001和P<0.005);肺心病并发呼吸衰竭时,血清液和尿的β_2-MG水平与PaCO_2呈正相关,与PaO_2呈负相关。测定β_2-MG可早期发现肺心病的肾功能损伤。作者并对肺心病肾功能损伤的因素进行了讨论。

Serum and urine levels of β_2-microglo-bulin(β_2-MG)were measured with radioim-mune assay in 40 chronic cor pulmonale pa-tiens (52 episodes) and 26 normal controls.The results Med that the serum andurine levels of β_2-MG were 2.01±0.47mg/Land 0.10±0.08mg/L respectively. in thenormal controls,while in the cor pulmonalegroup 3.86±1.58mg/L and 0.66±0.34mg/Lrespectively, with statistical significance(P<0.001, <0.005). It was shown thatthere was a positive correlation betwenthe levels of serum and urine β_2-MG andPaCO_2 and a negative correlation betweenthe levels of serum and urine β_2-MG andPaO_2. The Results indicated that determi-nation of serum and urine β_2-MG could beused in the early detection of the renal im-pairment in chronic cor pulmonale. Thepredisposing factors of renal dysfunction incor pulmonale were also discussed.