4-溴代百里香酚的合成

Synthesis process research of 4-bromothymol

以百里香酚为原料,通过溴取代反应合成4-溴代百里香酚。采用FTIR、1H NMR等手段对产物进行了表征,确定了产物结构。探讨了溶剂种类、溴代剂种类和用量、反应时间、反应温度和微波加热功率对产物得率的影响,得到适宜的工艺条件为:以N-溴代丁二酰亚胺为溴代剂,n(百里香酚)∶n(N-溴代丁二酰亚胺)=1∶1.5,溶剂为乙酸,反应温度为20℃,反应时间15min,微波反应功率500W。在上述条件下,4-溴代百里香酚的得率为65.1%。

4-bromothymol was synthesized by the bromination reaction using thymol as starting material. The product was characterized by FTIR,1H NMR and the product structure was determined. The effects of different solvent,the type and amount of bromine generation agent,the reaction time,the reaction temperature and microwave heating power on the yield of product were discussed. The N-bromobutanimide was used as bromine generation agent and the solvent was ethanol acetic acid. The optimum conditions were：n（thymol）∶n（N-bromobutanimide）=1∶1.5. The reaction temperature was 20℃,the reaction time was 15 min,the microwave heating power was 500 W. Under the above optimal conditions,4-bromothymol yield was 65.1%.