益气固本调免方治疗气阴两虚型IgA肾病热结咽喉证

Clinical Observation of Yiqi Guben Tiaomian Decoction in Throat-oriented Treatment of IgA Nephropathy

目的:应用益气固本调免方治疗气阴两虚型IgA肾病热结咽喉证,观察其对IgA肾病的临床疗效。方法:将79例IgA肾病患者随机分为两组;治疗组39例给予益气固本调免方治疗,对照组40例给予固本通络方治疗,疗程为2个月。结果:1治疗组咽部情况积分显著降低(P<0.01),对照组则无明显改善,治疗组与对照组比较有显著统计学差异(P<0.01)。2对照组尿红细胞数和24h尿蛋白定量降低(P<0.05),治疗组尿红细胞数和24h尿蛋白定量显著降低(P<0.01),组间疗效比较有显著统计学差异(P<0.01);治疗组总有效率为84.6%,对照组总有效率为57.5%,组间疗效比较有显著统计学差异(P<0.01)。3治疗组咽部情况积分与尿红细胞数(P<0.01),24h尿蛋白定量(P<0.05)呈正相关。结论:益气固本调免方通过清热利咽能有效治疗气阴两虚型IgA肾病热结咽喉证,改善IgA肾病的病情,可能为IgA肾病的防治提供新思路。

Objective： To investigate the clinical effect of Yiqi Guben Tiaomian decoction in throatoriented treatment of Ig A nephropathy patients with Qi and Yin deficiency syndrome. Method： Seventy-nine patients with Ig A nephropathy were randomly divided into treatment group（ 39 cases,Yiqi Guben Tiaomian decoction） and control group（ 40 cases,Guben Tongluo decoction）, with a two-month course of therapies.Result： 1 Scores of throat in treatment group were significantly reduced（ P〈0. 01）,while there was no significant improvement in control group,with significantly statistical difference（ P〈0. 01）. 2 Red blood cell count of urine and 24 h urinary protein excretion were reduced in control group（ P〈0. 05）,and significantly reduced in treatment group（ P〈0. 01）,with significantly statistical difference between two groups（ P〈0. 01）.The total effective rate was 84. 6% in treatment group and 57. 5% in control group,with significantly statistical difference between two groups（ P〈0. 01）. 3The positive relationship between the scores of throat and red blood cell count of urine（ P〈0. 01） as well as the level of 24 h urinary protein excretion（ P〈0. 05） was found.Conclusion： Yiqi Guben Tiaomian decoction is effective to throat-oriented treatment of Ig A nephropathy with Qi and Yin deficiency syndrome and improve the symptoms of Ig A nephropathy by clearing heat and relieving sorethroat,which may provide new insight for the therapy of Ig A nephropathy.