补肾益气类方药延缓骨骼肌线粒体功能退化的研究概况

Review of Research on Bushen Yiqi Prescription in Retarding Mitochondrial Function Degradation of Skeletal Muscle

采用文献综述法,分析线粒体结构、膜通透性、氧化损伤、呼吸功能、酶活性及线粒体生物合成与骨骼肌衰老的关系,探讨补肾益气类方药对衰老骨骼肌线粒体结构和功能的影响,为采取合适中药延缓骨骼肌衰老提供理论依据。研究发现随着机体逐渐衰老,骨骼肌线粒体呈现出结构退化、膜通透性改变、氧化损伤、呼吸功能、酶活性及线粒体生物合成能力下降等改变,补肾益气类方药可通过改善衰老骨骼肌线粒体的结构和功能,延缓骨骼肌的衰老,但其深层作用机制及作用途径尚不明晰。在中医药理论体系指导下,结合现代实验技术,多角度、多层次地探明补肾益气类方药在延缓骨骼肌衰退中的作用机制及构效关系,是开发此类方药过程中亟待解决的问题。

This article uses literature summary method to analyze relationship between mitochondrial structure, membrane permeability, oxidative damage, respiratory function, enzyme activity, mitochondria biosynthesis and skeletal muscle aging,it explores influence of Bushen Yiqi prescription on mitochondria structure and function of ageing skeletal muscle,in order to provide theory basis for taking appropriate traditional Chinese medicine to retard skeletal muscle ageing. It is found that,as body gradually aging,mitochondrial structure in skeletal muscle became disorder,permeability of mitochondrial membrane changed,mitochondria suffers oxidative damaged, respiratory function, enzyme activity and mitochondria biosynthesis decreased, Bushen Yiqi prescription can retard skeletal muscle aging through improving mitochondrial structure and function of aging skeletal muscle, but its deep mechanism of action was not clear. How to combine modern experimental technology,under guidance of theory system of traditional Chinese medicine, multi-angle and multi-level to ascertain mechanism and structure-activity relationship of Bushen Yiqi prescription in retarding skeletal muscle aging is the key issue to be solved in process of developing this kind of herbs and formulae.