摘要
IL-6是一种多效性前炎症细胞因子,具有多种生物学活性,包括介导炎症反应、免疫反应等。随着对IL-6及其受体信号通路研究的不断深入,IL-6现已成为一个有效的治疗靶点,在炎症及自身免疫性疾病的治疗过程中发挥重要作用。采用文献调研、数据库检索、数据统计与分析等定性定量情报学研究方法,从研发阶段、适应证、临床及上市药物等方面对全球IL-6靶标药物的研发情况进行分析,旨在为我国免疫药物的研发提供参考。
Interleukin-6（IL-6） is a multifunctional pro-infl ammatory cytokine with a variety of biological activities, including regulatory effects on infl ammation and immune response. With more and more researches conducted on IL-6 and its receptor signaling pathway, IL-6 has become an effective therapeutic target for infl ammation and autoimmune diseases. In this paper, qualitative and quantitative intelligence research methods such as literature investigation, database retrieval, as well as statistics and data analysis have been used to analyze the global research and development of drugs targeting IL-6, including development stage, indications, clinical data and marketed drugs, so as to provide reference for RD of immune modulating drugs in China.
出处
《药学进展》
CAS
2015年第11期870-873,共4页
Progress in Pharmaceutical Sciences
