间充质干细胞在炎症免疫调节中的作用及应用进展

Mesenchymal stem cells in the inflammatory immunomodulation

背景:研究表明,间充质干细胞的主要功能有直接参与损伤修复,分泌生长因子,调节免疫和炎症,抗氧化应激等,可用于治疗多种急、慢性疾病。目的:综述间充质干细胞在炎症免疫调节中的研究进展。方法:以"干细胞,间充质干细胞,免疫调节,炎症,免疫细胞,炎症因子,治疗"为中文检索词,以"stem cells,mesenchymal stem cells,immune regulation,inflammation,immune cells,inflammatory factors,treatment"为英文检索词,在万方、中国知网期刊全文数据库和Pub Med数据库检索2005年1月至2015年8月有关干细胞参与炎症免疫调节的文献。排除陈旧性和重复性研究,最终纳入40篇文献进行综述。结果与结论:间充质干细胞因其具有免疫调节及多向分化的特性,越来越受到临床的重视,同时间充质干细胞易于从不同组织中获取并且具有良好的体外扩增能力,使得其在组织损伤炎症与修复的临床运用中具有广阔的前景。作为最有希望进入临床应用阶段的种子细胞,间充质干细胞在许多疾病的治疗中表现出了它的优越性,特别是对于免疫调节失衡导致的炎症性相关疾病的治疗中表现出良好的效果。相信在未来的细胞生物治疗领域,间充质干细胞将占有重要的地位。

BACKGROUND： Studies have shown that the main functions of mesenchymal stem cells include direct participation in wound healing, growth factor secretion, promoting angiogenesis, immune regulation and inflammation, anti-oxidative stress, which can be used to treat a variety of acute and chronic diseases. OBJECTIVE： To review advances in mesenchymal stem cells in the inflammatory immunomodulation. METHODS： A computer-based search of Wanfang, CNKI and Pub Med databases was performed for articles concerning advances in mesenchymal stem cells in the inflammatory immunomodulation published from January 2005 to August 2015. The search terms were ＂stem cells, mesenchymal stem cells, immune regulation, inflammation, immune cells, inflammatory factors, treatment＂ in Chinese and English, respectively. Finally, 40 articles were included in result analysis.RESULTS AND CONCLUSION： Because of their immunomodulation and muti-directional differentiation,mesenchymal stem cells garner increasing attentions. In addition, mesenchymal stem cells can be harvested from different tissues and have good in vitro amplification capability, which have a broad prospect in the clinical use, including tissue repair and anti-inflammation. As the most promising cells used clinically, mesenchymal stem cells show their superiority in the treatment of many diseases, especially in inflammations induced by immune modulation imbalance. We believe that mesenchymal stem cells will play an important role in the future cell biotherapy.