Notch信号通路调控下的血管形成

Regulation of angiogenesis by Notch signaling

背景:Notch信号通路是一条在进化过程中高度保守的的近距离细胞间转导机制系统,广泛地参与各种组织细胞的分化、增殖和凋亡过程,在血管新生过程中参与协调血管内皮细胞的多方面功能,对血管网的形成和重塑起着关键作用。目的:对Notch信号通路的组成以及对血管新生的影响作一综述。方法:电子检索CBM和PubM ed数据库,中英文检索词分别为"Notch信号通路;血管形成;调控机制"和"Notch signaling pathway;angiogenesis;regulation mechanism"。选择性地纳入有关Notch信号通路调控血管形成方面的高质量的文献,排除重复发表文献。结果与结论:共纳入31篇文献。血管形成是复杂的,多阶段性的生物学事件并有着精密复杂的调控方式。Notch信号通过与血管内皮生长因子,BMP-SMAD信号通路、细胞外基质分子等交互对话,直接或间接地参与调控血管新生的各个阶段,而且持续的Notch信号是维持成体血管系统结构与功能的稳定所必需。文章阐明Notch通路调控血管形成的最新进展,且为针对血管疾病设计调控血管新生的治疗方法提供理论基础和治疗靶点。

BACKGROUND：The Notch signaling pathway is evolutionarily highly conserved and mediated by cel-cel interactions, which is widely involved in cel differentiation, proliferation and apoptosis. This critical transduction system participates in coordinating various functions of vascular endothelial cels, thus playing a vital role in the formation and remodeling of vascular network. OBJECTIVE： To elucidate the components of Notch signaling pathway and its impact on angiogenesis. METHODS： A computer-based online search of PubMed and CBM databases was performed. High-quality articles related to mechanism of angiogenesis regulated by Notch signaling were included, and repetitive studies were excluded. RESULTS AND CONCLUSION：Totaly 31 literatures were selectively included in this review. Angiogenesis is a complicated and muti-stage biological event and has been delicately regulated. Notch signaling participates in the regulation of every stage of angiogenesis directly or indirectly via the crosstalk with vascular endothelial growth factor, BMP-SMAD signaling and extracelular matrix molecules. Furthermore, consistent output of Notch signaling is essential for maintaining the stability and integrity of adult vascular system. This review wil thoroughly clarify the latest progress on angiogenesis regulated by Notch signaling and provide theoretical basis and a＆nbsp;potential target for designing therapeutic methods against vascular disease.