带血管蒂髌腱移植物的力学性能

Mechanical properties of vascularized patellar tendon graft

背景:临床上研究膝关节交叉韧带生物材料的力学性能具有重要意义,可为临床研制组织结构、生物力学及相容性好的材料提供理论依据。目的:分析带血管蒂髌腱移植物的力学性能。方法:切断42只新西兰大白兔左前腿前交叉韧带,随机分为2组,实验组植入自体带血管蒂髌腱移植物进行前交叉韧带修复,对照组植入自体不带血管蒂髌腱移植物进行前交叉韧带修复。移植后8,12,16周,检测两组移植标本的生物力学性能。结果与结论:两组不同时间点的断裂位置比较差异无显著性意义;实验组移植后12,16周的膝关节前后松弛度高于对照组(P<0.05),两组移植后8周的膝关节前后松弛度比较差异无显著性意义;实验组移植后8,12,16周的最大载荷均高于对照组(P<0.05),移植后8,12,16周的刚度均高于对照组(P<0.05);两组移植后不同时间点的最大拉伸长度比较差异无显著性意义。表明带血管蒂髌腱移植物具有良好的力学性能。

BACKGROUND：The clinical study on the mechanical properties of biomaterials for cruciate ligament reconstruction is of great importance, which can provide a theoretical basis for the clinical development of materials with good structure, biomechanics and compatibility. OBJECTIVE：To analyze the mechanical properties of vascularized patelar tendon graft. METHODS：The anterior cruciate ligaments of the left foreleg from 42 New Zealand white rabbits were cut off. Then, these rabbits were randomly and evenly divided into two groups： experimental group and control group. Rabbits in the experimental group were implanted vascularized patelar tendon graft for anterior cruciate ligament repair. Rabbits in the control group were implanted with autologous non-vascularized patelar tendon graft for anterior cruciate ligament repair. At the 8th, 12th and 16th weeks after implantation, biomechanical properties of specimens from these two groups were detected. RESULTS AND CONCLUSION： There was no significant difference on the fracture location at different time points between these two groups; at the 12th and 16th weeks after transplantation, the knee laxity in the experimental group was higher than that in the control group （P 〈 0.05）. At the 8th week after transplantation, there was no significant difference in the knee laxity between these two groups. At the 8th, 12thand 16th weeks after transplantation, the maximum load in the experimental group was higher than that in the control group （P 〈 0.05）. At the 8th, 12th and 16th weeks after transplantation, the stiffness in the experimental group was higher than that in the control group （P 〈 0.05）. There was no significant difference in the maximum tensile elongation between these two groups at different time points after transplantation. These results demonstrate that vascularized patelar tendon graft has good mechanical properties.