摘要
叶黄素(Lutein)是一种含氧的类胡萝卜素。由于人体不能合成,其主要来源为食物。多项研究显示,叶黄素对包括糖尿病视网膜病变在内的年龄相关性退行性眼病具有保护作用。动物和细胞研究提示叶黄素可通过缓解高血糖诱导的氧化应激反应,起到保护视网膜血管内皮细胞,减少视网膜新生血管形成,达到减轻视网膜损伤的效用。本文将阐述叶黄素在预防和控制糖尿病视网膜病的发生发展等方面作用机制和研究现状。
Lutein belongs to the xanthophyll family of carotenoids,which are mainly synthesized from dark green leafy plants.Evidence from several studies has shown that patients with age-related degenerative eye disease including diabetic retinopathy（DR）,may benefit from oral lutein intake.Animal and cell researches suggest that lutein,through oxidative stress induced by hyperglycemia remission,could protect retinal vascular endothelial cells,reduce formation of retinal neovascularization,and therefore mitigating possible retinal damages.This article reviews the results and possible mechanisms of lutein on DR at cellular and molecular level,offering insights in prevention and control measures of DR.
出处
《国外医学（医学地理分册）》
CAS
2015年第4期311-313,共3页
Foreign Medical Sciences：Section of Medgeography
基金
国家自然科学基金资助项目(No.81202198)
中央高校基本科研业务费专项资金资助项目(No.xjj2012052)
西安交通大学"新教师科研支持计划"资助项目
