维生素D受体在胃癌中的表达及临床病理意义

The expression and clinicopathological significance of vitamin D receptor in gastric cancer

目的探讨维生素D受体(VDR)在胃癌发生过程及不同分化水平、不同分期胃癌的表达差异。方法采用免疫组化Envision法检测VDR在140例胃正常组织、胃癌前病变(异型增生)及胃癌中的表达,并分析VDR在不同分化、不同分期胃癌的表达。结果 1胞浆VDR阳性细胞百分比随癌变下降,而核VDR表达强度及阳性细胞百分比则升高;2低分化组胞核VDR表达强度和阳性细胞百分比均较中高分化组为高;3进展期胃癌细胞核VDR的表达强度较早期升高。结论胃癌发生及进展过程中细胞浆内的VDR表达存在下降趋势,同时细胞核VDR表达异质性增强,存在少量细胞上调核内VDR表达水平。

Objective To explore the different expression of vitamin d receptor（VDR）during the onset of gastric cancer and in the gastric cancers of different differentiation level and different stage.Methods Envision method was applied to detect the expression of VDR in 140 cases of normal gastric tissue,precancerous lesion（atypical hyperplasia）and the gastric cancer,and we analyzed the expression of VDR in different differentiation and stage gastric cancer.Results （1） The percentage of cytoplasmic VDR positive cells（PCV）declined with tumorigenesis,while the nuclear expression intensity of VDR（NIV）and percentage of nuclear VDR positive cells（PNV）increased;（2） The NIV and PNV of the low differentiation group were higher than those of moderate-high differentiation group;（3 ）The NIV of progressed gastric cancer was higher than that of early gastric cancer.Conclusion The cytoplasmic expression of VDR was inclined to decrease during the onset and progress of gastric cancer,while the heterogeneity of VDR expression in nucleus increased with the enhancement of nuclear VDR expression levels in few cells.