中年人血尿酸水平与高血压及正常高值血压的相关性研究

Relationship Among Serum Uric Acid, Hypertension, and Prehypertension in Middle-Aged People

【目的】探讨中年人群血尿酸（UA）水平与高血压及正常高值血压的相关性。【方法】以沈阳市1613名35～64岁常住中年社区居民为研究对象，根据其血压水平将其分为高血压组、正常高值组、血压正常组。根据研究对象UA四分位不同将其分为A组（〈238．5μmol／L），B组（238．5～282．8μmol／L），C组（282．8～335．4μmol／L），D组（≥335．4μmol／L）。通过问卷调查、体格测量及检测相关生化指标，应用单因素和多因素分析方法，分析UA水平与高血压及正常高值血压的相关性。【结果】高血压组、正常高值组、血压正常组三组间年龄、UA、体质量指数（BMI）、空腹血糖（FPG）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）水平均存在显著性差异（均P〈0．05）。与A组比较，D组收缩压（SBP）、舒张压（DBP）均显著高于A组，差异具有统计学意义（P〈0．05）。Pearson相关性分析结果显示，SBP与UA成显著正相关（r=0．195，P〈0．01），DBP与UA成显著正相关（r=0．224，P〈0．01）。调整多因素后，UA水平最高四分位D组进展为高血压和正常高值血压的危险分别是UA最低四分位A组的2．31倍（95％CI，1．51～3．54，P〈0．01）和1．52倍（95％CI，1．03～2．22，P〈0．01）。【结论】血清UA水平与高血压及正常高值血压存在正相关性，早期控制血清UA水平及血压水平，对减少心血管事件的发生有重要意义。

[Objective] To study the relationship among serum uric acid, hypertension, and prehypertension in middle-aged people. [Methods]The 1,613 community residents aged 35-64 years who lived in Shenyang city were investigated. The associations among uric acid, hypertension, and prehypertension were analyzed though questionnaire survey, physical examination and biochemical detection. [Results] Means of uric acid levels were （317.32±81.25） μmol/L, （292.35±73.21） μmol/L, and （271.76±63.03） μmol/L in hypertensives, prehypertensives and normotensives respectively, with significant differences among the three groups （ P 〈 0.05）. The mean level of systolic/diastolic blood pressures were （ 121.04 ± 17.54）/（73.08 ± 10.63） mmHg, （123.76±19.81）/（75.67±11.75）mmHg, （123.91±18.69）/（75.23±10.61）mmHg, and （131.08±19.54） / （80.02± 11.19） mmHg for these with uric acid level in the first, second, third, and fourth quartiles. Adjusted odd ratios of hypertension and prehypertension in quartile 4 of uric acid were 2.31 （95 % CI：1.51- 3.54, P 〈 0.01） and 1.52 （95%CI：1.03-2.22, P 〈0.01）, with quartile 1 as a reference. [Conclusion] Serum uric acid level is associated with both hypertension and prehypertension in middle-aged people. Therefore serum uric acid monitoring should be paid attention to.