摘要
【目的】探讨中年人群血尿酸(UA)水平与高血压及正常高值血压的相关性。【方法】以沈阳市1613名35~64岁常住中年社区居民为研究对象,根据其血压水平将其分为高血压组、正常高值组、血压正常组。根据研究对象UA四分位不同将其分为A组(〈238.5μmol/L),B组(238.5~282.8μmol/L),C组(282.8~335.4μmol/L),D组(≥335.4μmol/L)。通过问卷调查、体格测量及检测相关生化指标,应用单因素和多因素分析方法,分析UA水平与高血压及正常高值血压的相关性。【结果】高血压组、正常高值组、血压正常组三组间年龄、UA、体质量指数(BMI)、空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)水平均存在显著性差异(均P〈0.05)。与A组比较,D组收缩压(SBP)、舒张压(DBP)均显著高于A组,差异具有统计学意义(P〈0.05)。Pearson相关性分析结果显示,SBP与UA成显著正相关(r=0.195,P〈0.01),DBP与UA成显著正相关(r=0.224,P〈0.01)。调整多因素后,UA水平最高四分位D组进展为高血压和正常高值血压的危险分别是UA最低四分位A组的2.31倍(95%CI,1.51~3.54,P〈0.01)和1.52倍(95%CI,1.03~2.22,P〈0.01)。【结论】血清UA水平与高血压及正常高值血压存在正相关性,早期控制血清UA水平及血压水平,对减少心血管事件的发生有重要意义。
[Objective] To study the relationship among serum uric acid, hypertension, and prehypertension in middle-aged people. [Methods]The 1,613 community residents aged 35-64 years who lived in Shenyang city were investigated. The associations among uric acid, hypertension, and prehypertension were analyzed though questionnaire survey, physical examination and biochemical detection. [Results] Means of uric acid levels were (317.32±81.25) μmol/L, (292.35±73.21) μmol/L, and (271.76±63.03) μmol/L in hypertensives, prehypertensives and normotensives respectively, with significant differences among the three groups ( P 〈 0.05). The mean level of systolic/diastolic blood pressures were ( 121.04 ± 17.54)/(73.08 ± 10.63) mmHg, (123.76±19.81)/(75.67±11.75)mmHg, (123.91±18.69)/(75.23±10.61)mmHg, and (131.08±19.54) / (80.02± 11.19) mmHg for these with uric acid level in the first, second, third, and fourth quartiles. Adjusted odd ratios of hypertension and prehypertension in quartile 4 of uric acid were 2.31 (95 % CI:1.51- 3.54, P 〈 0.01) and 1.52 (95%CI:1.03-2.22, P 〈0.01), with quartile 1 as a reference. [Conclusion] Serum uric acid level is associated with both hypertension and prehypertension in middle-aged people. Therefore serum uric acid monitoring should be paid attention to.
出处
《医学临床研究》
CAS
2015年第12期2307-2309,2313,共4页
Journal of Clinical Research
基金
辽宁省科技厅社会发展攻关计划项目(2011-404013-6)
关键词
尿酸/血液
高血压
血压
问卷调查
体格检查
Uric Acid/BL
Hypertension
Blood Pressure
Questionnaires
Physical Examination