小剂量低分子肝素钙联合传统安胎法治疗D-D异常升高复发性流产的疗效观察

Observation of effect of small doses low molecular heparin combined traditional treatment method for the D-D abnormal increase in recurrent spontaneous abortion

目的 研究小剂量低分子肝素钙联合传统安胎法治疗D-二聚体（D-D）异常升高复发性流产的疗效。方法选取2014年1-12月我院收治的124例D-D异常升高复发性流产患者,依照随机数字法分为观察组和对照组各62例,对照组采用阿司匹林＋黄体酮＋维生素E保胎治疗,观察组在此基础上应用小剂量低分子肝素钙治疗,观察并对比两组患者的临床治疗效果。结果 观察组患者孕期腰骶酸痛、阴道流血、下腹疼痛或坠胀等现象显著少于对照组（P〈0.05）,妊娠成功率高于对照组,妊娠失败患者最长妊娠时间及平均妊娠时间均显著长于对照组,差异有统计学意义（P〈0.05）;两组患者不良反应差异无统计学意义（P〉0.05）。结论 小剂量低分子肝素钙联合传统安胎法治疗D-D异常升高复发性流产具有安全、有效的特点,有利于提高妊娠成功率,值得推广应用。

Objective To explore the effect of small dose low molecular heparin calcium combined traditional treatment method for the fetus D-dimer（D-D） abnormal increase in recurrent spontaneous abortion.Methods Selected 124 cases of D-D abnormal increase in recurrent spontaneous abortion in our hospital from January to December 2014,who were randomly divided into observation group and control group,62 cases in each group,The control group was treated with aspirin＋progesterone＋vitamin E tocolytic therapy,the observation group added small dose low molecular weight heparin calcium in the treatment,the clinical effect between the two groups was observed.Results Pain during pregnancy lumbosacral,vaginal bleeding,abdominal pain or fall swell phenomenon in observation group were significantly lower than that of the control group（P〉0.05）,the pregnancy success rate,the longest duration of gestation and mean time to pregnancy in observation group were significantly higher than those in control group,the difference were statistically significant（P〈0.05）.Two adverse reactions of two groups had no statistical significance（P〈0.05）.Conclusion Small dose low molecular heparin calcium combined traditional treatment method for the fetus D-D abnormally elevated in patients with recurrent abortion safe,effective,and it is helpful to improve the treatment success.