中药复方大黄液对急性脑梗死伴便秘患者小肠传递时间及预后的影响

Effect of Chinese herb compound rhubarb on small bowel transit time and prognosis in patients with acute cerebral infarction with constipation

目的探讨复方大黄液对急性脑梗死患者小肠传递时间(small bowel transit time,SBTT)及预后的影响。方法①72例急性脑梗死患者随机分为中药治疗组和对照组,治疗组在常规治疗基础上使用复方大黄液,通过呼气氢试验(breath hydrogen test,BHT)测定治疗组治疗前后及对照组的SBTT。②30 d时利用改良Rankin量表(modified Rankin Scale,mRS)分为转归良好组与转归不良组,进行统计学分析。结果①治疗组治疗前后SBTT分别为(110.3±22.5)min和(78.6±15.3)min,差异有高度统计学意义(P<0.01);对照组SBTT为(105.8±21.6)min,与治疗组治疗前比较,差异无统计学意义(P>0.05);中药治疗组转归良好28例,转归不良8例,对照组为20例和16例,差异有统计学意义(P<0.05);②SBTT与急性脑梗死患者30 d时预后相关(P=0.004,OR=1.252,95%可信区间)。结论复方大黄液能缩短急性脑梗死患者小肠传递时间,改善疾病预后;SBTT延长是影响急性脑梗死患者预后的危险因素之一。

Objective To investigate the effect of compound rhubarb liquid on small bowel transit time（SBTT） and prognosis in patients with acute cerebral infarction.Methods ①72 cases of patients with acute cerebral infarction were randomly divided into treatment group and control group.The treatment group was＇ used compound rhubarb liquid on the basis of conventional treatment.Through hydrogen breath test（BHT）,we determined SBTT of treatment group（before and after treatment） and control group.②After 30 days,cases were divided into the good prognosis group and the poor prognosis group by modified rankin scale（mRS）,and results were statistically analyzed.Results ①The SBTT of treatment group before and after treatment were（110.3±22.5） min and（78.6±15.3） min,there was significant difference（P〈0.01）;control group got（105.8±21.6）min,there was no significant difference（P〉0.05）between control group and treatment group before treatment.The good prognosis was 28 cases and the poor prognosis was 8 cases in treatment group,in control group were 20 cases and 16 cases,there was difference between treatment group and control group（P〈0.01）.②SBTT was associated with the prognosis of acute cerebral infarction after 30 days（P=0.004,OR=1.252,95%CI）.Conclusion Compound rhubarb liquid can shorten the small bowel transit time in patients with acute cerebral infarc tion,and improve the prognosis;The long SBTT is one of the risk fators that effected the prognosis in patients with acute cerebral infarction.