胰腺癌患者肿瘤相关性贫血干预情况研究

A study of the anemia epidemiology and treatment status of pancreatic cancer patients

目的了解肿瘤科胰腺癌患者的贫血发病情况,对贫血的相关因素及治疗情况进行分析,为采取相应对策改善患者贫血提供依据。方法采用问卷调查的方法,对就诊于首都医科大学附属北京友谊医院的65例胰腺癌患者进行流行病学研究,并留取血液学样本检测红细胞、血红蛋白含量。结果共收集65例有效调查问卷,受试患者的贫血发生率为66.2%,且随着化疗次数、疾病分期的增加贫血发生率升高。接受贫血治疗者为52.2%,以中成药治疗为主。多因素分析显示,女性、消瘦、健康管理差、体能评分差为胰腺癌患者发生贫血的独立危险因素。结论针对胰腺癌贫血的高危人群,及时有效的贫血干预非常重要,补充促红细胞生成素和铁剂等的治疗还需进一步完善。

Objective To investigate the factors that might be related to anemia and treatment status of pancreatic cancer,in order to improve the treatment of patients in pancreatic cancer patient with anemia. Methods The patients with pancreatic cancer visited the oncology outpatient service of Beijing Friendship Hospital had peripheral blood tested and were surveyed with questionnaire. Statistical analysis was made by SPSS version 16. 0. Results Of 65 pancreatic cancer patients,the incidence of anemia was 66. 2%,and the incidence increased with the times of chemotherapy and disease stage. 52. 2% of the patients received treatment for anemia. Multiple factors analysis showed that female,BMI 18. 5,ECOG 3- 4,poorly health management were the independent risk factors for anemia in patients with pancreatic cancer. Conclusion Timely and effective anemia intervention is very important for pancreatic cancer patients who are at high- risk to develop anemia. The development of erythropoietin therapy and iron therapy is needed to improve treatment outcomes of anemia in pancreatic cancer patients.