抗菌药物对老年糖尿病合并肺部感染患者内皮素及降钙素基因相关肽的影响

Study on the influence of antibiotics on endothelin and calcitonin gene related peptides in elderly patients with diabetes mellitus complicated with pulmonary infection

目的探讨抗菌药物对老年糖尿病合并肺部感染患者内皮素(ET)和降钙素基因相关肽(CGRP)含量变化的影响。方法回顾性分析2013年1月至2014年12月收治的73例老年糖尿病合并肺部感染患者的临床治疗资料,观察抗菌药物治疗后患者的ET和CGRP含量变化。结果经抗菌药物治疗治疗,老年糖尿病合并肺部感染患者血浆ET水平比治疗前显著降低,CGRP比治疗前明显升高。结论 ET及CGRP参与了糖尿病合并肺部感染患者的病理过程,合理使用抗生素不但及时消除患者肺部感染,也纠正了患者ET和CGRP水平的异常,有利于病情整体控制。

Objective To explore the effect of antibiotics on changes of endothelin（ ET） and calcitonin gene related peptides（ CGRP） in aged patients with diabetes mellitus complicated by pulmonary infection. Methods The clinical data of 73 elderly diabetes patients complicated with pulmonary infection during January 2013 to December 2014 were retrospectively analyzed in order to observe the changes of contents of ET and CORP caused by antibacterial drugs in treatment of these patients. Results The plasma level of ET in elderly patients with diabetes mellitus complicated with pulmonary infection was significantly lower than that before treatment,and the level of CGRP was significantly higher than that before treatment. Conclusion ET and CGRP were participated in the pathological process of pulmonary infection in patients with diabetes mellitus,and the rational application of antibiotics not only can timely eliminate the pulmonary infection in these patients,but also correct the imbalance between ET and CGRP,and it is beneficial to the control of disease.