美沙拉嗪治疗老年溃疡性结肠炎的临床效果观察

Observation on clinical effect of mesalazine in treating elderly ulcerative colitis

目的探讨美沙拉嗪治疗老年溃疡性结肠炎(UC)的临床效果。方法选择该院收治的68例老年UC患者随机分为观察组和对照组各34例,其中使用美沙拉嗪治疗的为观察组,使用柳氮磺吡啶治疗的为对照组。比较两组患者治疗前后临床症状、结肠镜检查结果、大便次数及肝肾功能的变化。结果观察组患者的总有效率为94.1%,对照组为79.4%,观察组治疗效果优于对照,差异有统计学意义(P<0.05);观察组不良反应发生率为8.8%,对照组为29.4%,差异有统计学意义(P<0.05)。结论美沙拉嗪治疗老年UC具有明显的治疗效果,并且药物的不良反应低,安全性较高。

Objective To investigate the clinical effect of mesalazine in treating elderly ulcerative colitis（UC）. Methods 68 cases of elderly UC in our hospital were selected and randomly divided into the observation group （using mesalazine） and the control group （using sulfasalazine）, 34 cases in each group. The clinical symptoms, coIono scopic results, defecate frequency and the change of liver and kidney function were compared between the two groups. Results The total effective rate of the observation group was 94.10%, which of the control group was 79.4%, the treatment effect of the observation group was better than that of the control group, the difference was statistically significant （P〈0.05）. The occurrence rate of adverse reactions was 8.8% in the observation group and 29.4% in the control group,the difference was statistically significant （〈0.05）. Conclusion Mesalazine has the remarkable effect with lower adverse drug reaction and higher security in the treatment of elderly UC.