基于TGF-β1/Smads信号通路中医药防治哮喘气道重塑研究进展

Research Progress on the Treatment of TCM for Airway Remodeling of Asthma Based on the TGF-β 1/Smads Signaling Pathway

小儿支气管哮喘是儿科临床常见性、难治性疾病,中医药在治疗小儿支气管哮喘方面具有显著优势,但其作用机制目前尚未完全阐明。国内外研究发现TGF-β1/Smads信号通路与哮喘气道重塑具有密切关系。该文对TGF-β1/Smads信号通路的信号转导途径和生物学功能进行了详细的阐述,综述了TGF-β1/Smads信号通路与小儿支气管哮喘气道重塑之间的相关性以及中医药通过对TGF-β1/Smads信号通路的调控作用治疗小儿支气管哮喘的机制。同时,对TGF-β1/Smads信号通路在中医药中的研究进行了展望。

The Bronchial asthma in children is common and refractory disease in the pediatric clinic.TCM has significant advantage in the treatment of asthma,but at present,the mechanisms is yet not well clarified. The TGF-β1/Smads Signaling Pathway is intimately linked with the airway remodeling of asthma in the reports at home and abroad. The article summarizes the signal transduction and biological function of TGF-β1/Smads Signaling Pathway,and the correlation between TGF-β1/Smads Signaling Pathway and airway remodeling of asthma. Meanwhile,the article reviews the machanism research of TCM on the treatment for asthma by regulating the TGF-β1/Smads Signaling Pathway,and looks ahead the research direction of the TGF-β1/Smads Signaling Pathway in TCM.