原发性中枢神经系统淋巴瘤的治疗

Treatment of primary central nervous system lymphoma

原发性中枢神经系统淋巴瘤（PCNSL）是一种较少见的中枢神经系统恶性肿瘤,总体预后欠佳,主要治疗方法包括手术、放疗和化疗.立体定向活检术以其微创、便捷的优点,已经成为确诊PCNSL的常规方法.全脑放疗是多病灶性PCNSL的标准化治疗方法,可短期内延缓肿瘤进展.以大剂量甲氨蝶呤为基础的治疗方案大大改善了PCNSL的治疗效果,成为PCNSL的有效治疗措施.有效的综合治疗是延长PCNSL患者生存期和改善生命质量的关键.

As a kind of rare central nervous system malignant tumor, primary central nervous system lymphoma （PCNSL） has poor prognosis, and the main treatment include surgery, radiotherapy and chemotherapy.Stereotactic biopsy has become a routine diagnostic method of PCNSL, because of which has the advantage of minimally invasive and convenient.Whole brain radiotherapy is a standardized treatment method for the multifocal PCNSL, which can delay the progress of tumor in a short term.The therapeutic regimen based on high dose methotrexate leads to significant changes in the PCNSL treatment and it has become an effective treatment measure.Effective comprehensive treatment is the key to extending survival time and improving the quality of life for the patients with PCNSL.