5-氨基酮戊酸光动力疗法治疗面部扁平疣疗效观察

Clinical observation of topical photodynamic therapy for facial flat warts

目的:探讨5-氨基酮戊酸光动力疗法(5-aminolevulinic acid photodynamic therapy,ALA-PDT)治疗面部扁平疣的临床疗效。方法:将入选的患者随机分为两组。治疗组:28例,用5-氨基酮戊酸光动力疗法治疗,1次/周,共3周;对照组:30例,外擦1%喷昔洛韦乳膏,2次/d,同时外用0.1%维A酸霜,每晚1次。疗程结束后判定疗效并随访3个月。结果:治疗组有效率、痊愈率分别为96.43%、89.29%,对照组有效率、痊愈率分别为63.34%、36.67%,两组疗效比较差异有统计学意义(P<0.05)。随访3个月,治疗组复发率12.00%,对照组复发率36.34%,治疗组复发率低于对照组,差异有统计学意义(P<0.05)。结论:ALA-PDT是目前比较安全、高效的治疗扁平疣的方法。

Objective To observe the effect of 5-aminolevulinic acid photodynamic therapy for facial flat warts. Methods 58 patients with facial flat warts were randomly divided into two treatment groups,the treatment group with 28 patients were treated with 5-aminolevulinic acid photodynamic therapy once a week for three weeks in total,while 30 cases in the control group received combined topical treatment of penciclovir cream twice a day and 0.1% all-trans retinoic acids cream once a day for four weeks. Results The total effective rates and cure rates of treatmet group was 96.43, 89.29% respectively,while the control group was 63.34%,36.67% respectively.There was a significant difference between the two groups（P〈0.05）.The recurrence rate of treatment group was 12% while the control group was 36.34% in the follow-up. Conclusion Topical 5-aminolevulinic acid ohotodvnamic theraDv for facial flat warts has hiah safetv and sianificant effect.