老年COPD患者血浆内皮素和降钙素基因相关肽水平测定

Examine plasma endothelin and calcitonin gene-related peptide levels in patients with chronic obstructive pulmonary disease

目的研究血浆内皮素 (ET 1)和降钙素基因相关肽 (CGRP)对慢性阻塞性肺病 (COPD)的影响 ,以探讨其改变在COPD病理生理过程中的作用。方法测定 4 8例老年COPD患者及健康对照组 30例ET 1及CGRP水平 ,并将COPD组分为急性发作期 (A组 ) 34例及临床缓解期 (B组 ) 14例 ,测定A组治疗前后血浆ET 1、CGRP水平 ,以及PoO2 、SaO2 浓度。结果老年COPD组血浆ET 1(41 2 5±2 1.4 3ng L)明显高于对照组 (2 7.2 1± 12 .73ng L)老年COPD组血浆CGRP(6 7 2 6± 31.6 0ng L)明显高于对照组 (39 75± 7.85ng L) ,二者与对照组相比较 ,差异均有显著意义 (P <0 0 1)。COPDA组治疗前后血浆ET 1、CGRP比较 ,治疗后ET 1水平 (35 11± 13.0 6ng L)较治疗前降低 (6 3 4 7± 2 9.12ng L) ,差异有显著意义 ,CGRP治疗后水平 (112 4 2± 71.87ng L)较治疗前升高 (84 12± 36 .0 9ng L) ,差异有显著意义。并且ET 1水平与动脉血氧分压 (PaO2 )及血氧饱和度 (SaO2 )呈负相关 ,CGRP水平与PaO2 、SaO2 呈正相关。结论缺氧状态下的ET 1。

Objective To explore the effects of plasma endothlin (ET-1) and calcitonin gene-related peptide(CGRP) levels on the chronic obstructive pulmonary disease (COPD). Methods The levels of plasma ET-1 and CGRP were determined in 48 cases of COPD and 30 cases of normal control. The patients with COPD were divided into acute attact period (group A) and alleviation period (group B), and the levels of plasma ET-1 and CGRP were determined both before and after the treatment. Results The plasma ET-1 and CGRP levels of patients with COPD were significantly higher than those of controls ( P <0.01). The level of ET-1 was decreased remarkably and the level of CGRP was increased remarkably after the treatment in group A,and the level of ET-1 had significantly negative correlation with PaO2 and SaO2, the level of CGRP had significantly positive correlation with PaO 2 and SaO 2. Conclusion The results demonstrated that the disorder of ET-1 and CGRP under hypoxia were some important change in pathologic physiology of COPD.