创伤患者早期血清可溶性E-选择素水平及其临床意义

Serum level of soluble E-selectin and the clinical significance in patiants after trauma

目的探讨血清可溶性E 选择素 (sE -selectin简称血清sE 选择素 )在创伤早期的变化及其临床意义。方法应用双抗体夹心ELISA法分别检测 30例创伤患者及 2 0例健康人血清sE 选择素水平。结果创伤早期血清sE 选择素水平明显高于正常对照 (P <0 0 1) ;重症组血清sE 选择素水平明显高于轻症组 (P <0 0 1)。结论初步研究表明血清sE 选择素水平在创伤后升高 ,并与创伤严重程度密切相关 ,检测血清sE

Objective To observe the level of serum soluble E-selectin(sE-selectin) in patiants after trauma and to study the clinical significance . Methods The sE-selectin levels of the serum were measured by enzyme-linked immunoabsorbent assay(ELISA) in 30 patiants after trauma and 20 health peoples . Results In compared with controls, the average serum levels of sE-selectin were much higher in patiants after trauma ( P <0.01), sE-selectin levels in the severity trauma were much higher than light group ( P <0.01). Conclusion The pilot study indicated that the average serum levels of sE-selectin rised in patiants after trauma and the sE-selectin was positively correlated with the degree of trauma. Measurement of serum sE-selectin might provide a importance guideline for monitoring the clinical courses of trauma.