奥氮平与氯氮平治疗精神分裂症的疗效与安全性研究

Study on the Effectiveness and Safety of Olanzapine and Clozapine in the Treatment of Schizophrenia

目的:比较奥氮平与氯氮平治疗精神分裂症的疗效与安全性。方法:选取2014年1月-2015年3月在本院精神科住院治疗的200例精神分裂症患者,按照随机数字表法将其分为试验组(奥氮平组)和对照组(氯氮平组),每组100例。试验组给予奥氮平治疗(12.5±2.5)mg/d,对照组口服氯氮平(312±32)mg/d,治疗8周。从PANSS评分、CGI-S评分、CGI-I评分及PSP评分评价其疗效,从TESS评分评价其安全性。结果:治疗后,试验组患者的PANSS评分、CGI-S评分、CGI-I评分及PSP评分分别为(44.8±8.2)、(2.49±0.41)、(2.88±0.36)、(74.6±6.7)分;对照组患者的PANSS评分、CGI-S评分、CGI-I评分及PSP评分分别(45.3±9.1)、(2.51±0.42)、(2.91±0.37)、(73.9±6.4)分。两组患者的PANSS评分、CGI-S评分、CGI-I评分均显著降低,PSP评分均明显增加,与治疗前比较差异均有统计学意义(P<0.05或P<0.01),组间比较差异均无统计学意义(P>0.05)。试验组和对照组的总有效率分别为70.0%和66.0%,比较差异无统计学意义(P>0.05)。试验组的TESS评分(5.12±0.94)分明显低于对照组的(7.89±2.16)分,比较差异有统计学意义(P<0.05)。结论:奥氮平治疗精神分裂症的疗效与氯氮平相当,安全性优于氯氮平,值得临床推广应用。

Objective：To observe the efficacy and safety of Olanzapine and Clozapine in the treatment of patients with schizophrenia.Method：Participants included 200 patients with schizophrenia who were hospitalized in our hospital from January 2014 to March 2015 were randomly divided into the experimental group（the Olanzapine group） and the control group（the Clozapine group）,100 cases in each group.The patients in the experimental group were given Olanzapine（12.5±2.5）mg/d and the patients in the control group were given oral Clozapine（312±32）mg/d for eight weeks.The PANSS score,CGI-S score,CGI-I score and PSP score were recorded to evaluate the efficacy.The TESS score was recorded to evaluate the safety.Result：After treatment,the PANSS score,CGI-S score,CGI-I score and PSP score of the experimental group were（44.8±8.2）,（2.49±0.41）,（2.88±0.36） and（74.6±6.7）scores,respectively.And the PANSS score,CGI-S score,CGI-I score and PSP score of the control group were（45.3±9.1）,（2.51±0.42）,（2.91±0.37） and（73.9±6.4）scores,respectively.The PANSS score,CGI-S score,CGI-I score in the both group were significantly reduced,and the PSP score was significantly increased,there were statistically significant differences compared with before treatment（P〈0.05 or P〈0.01）,there were no statistically significant differences between the two groups（P〉0.05）.The total efficiency rate of the experimental group and the control group were 70.0% and 66.0% respectively,there was no statistically significant difference（P〉0.05）.The TESS score of the experimental group was（5.12±0.94）scores,which was significantly lower than（7.89±2.16）scores of the control group,the difference was statistically significant（P〈0.05）.Conclusion：The Olanzapine and Clozapine have similar efficiency in the treatment of schizophrenic patients,and the Olanzapine is safer than Clozapine,is worthy of clinical popularization and application.