联合用药治疗原发型高血压临床疗效分析

Analysis on Clinical Effects of Drug Combination in Treating Essential Hypertension

目的:观察红花黄素注射液、丹参注射液、生脉注射液、低分子右旋糖酐联合治疗原发型高血压的临床疗效与安全性。方法:将原发性高血压患者120例予红花黄素注射液、丹参注射液、生脉注射液、低分子右旋糖酐等7种中西药制剂联合治疗,为治疗组;同期健康的120名志愿者为对照组,不作任何治疗,4周后进行疗效评价,随访14年。结果:治疗第2周,治疗组患者收缩压(136.54±10.68)mm Hg、舒张压(85.92±8.39)mm Hg较治疗前收缩压(146.63±9.10)mm Hg、舒张压(96.35±7.92)mm Hg降低(P<0.05)。治疗第4周,治疗组患者收缩压(124.28±11.49mm Hg)、舒张压(82.34±8.84)mm Hg较治疗前降低(P<0.05),接近正常对照组(P>0.05);治疗前后心率比较无明显差异(P>0.05);治疗组总有效率为76.6%,且无严重不良事件发生;随访14年中,93.5%患者未发生心脑血管疾病。结论:红花黄素射液、丹参注射液、生脉注射液、低分子右旋糖酐等7种中西药制剂联合治疗原发型高血压疗效满意,无不良反应,患者耐受性良好。

Objective： To investigate curative effects and the safety of safflower yellow injection, Do.aShen injection, ShengMai injection and low molecular weight dextran-40 in the treatment of essential hypertension （EH）. Methods： All 120 EH patients who received combined therapy including safflower yellow injection, DanShen injection, ShengMai injection and low molecular weight dextran-40 were taken as the treatment group; at the same time, 120 volunteers were chosen as the control group and left unhandled, clinical effects were assessed in four weeks and the patients were followed for 14 years. Results： In the second week after treating, systolic pressure and diastolic pressure of the treatment group were （136.54~10.68） mmHg and （85.92~8.39） mmHg, which decreased compared with （146.63~9.10） mmHg and （96.35~7.92）mmHg before treating （1~〈0.05）. In the forth week after treating, sys- tolic pressure and diastolic pressure of the treatment group were （124.28~11.49） mmHg and （82.34~8.84） mmHg, they lowered compared with before treating （P〈0.05）, closing to normal control group （P〉0.05）; there was no sig- nificant difference in the comparison of heart rate between before and after treating （P〉0.05）; total effective rate of the treatment group was 76.6%, and there was no severe adverse reaction happened; in the 14-year follow-ups, 93.5% of the patients didn＇t suffer from cardiovascular disease. Conclusion： Drug combinations including safflower yellow injection, DanShen injection, ShengMai injection and low molecular weight dextran-40 could obtain satisfactory effects in treating EH without adverse reaction and the patients show good tolerance.