扩散张量磁共振在评估精神分裂症患者脑部结构连接性异常中的应用现状

Advances of DTMRI in evaluating abnormal brain structural connectivity of patients with schizophrenia

精神分裂症(schizophrenia,SZ)与断裂综合征导致大脑连接的纤维破坏相关,患者的白质容量较健康人群明显减少。近年来得到发展的扩散张量磁共振成像(diffusion tensor MRI,DTMRI)作为一种无创成像技术,对微组织结构特征和白质纤维解剖等非常敏感。本文对文献中采用DTMRI为检测手段评估SZ高危者、初发SZ未治者及经治SZ患者脑部结构连接性异常的文献做一综述,旨在探讨SZ不同疾病阶段白质变化的主要模式,为临床诊疗提供参考。

The occurrence of schizophrenia（ SZ） is closely associated with the damage of brain connection fiber induced by nijmegen breakage syndrome,and SZ patients have less white matter volume than healthy populations. In recent years,the advanced diffusion tensor（ DT） magnetic resonance imaging（ MRI）,as a non-invasive imaging technique,is quite sensitive to micro- tissue structural characteristics and white matter fiber anatomy. By reviewing the literatures with abnormal brain structural connectivity of high-risk SZ patients,incipient SZ patients without treatment and treated SZ patients evaluated using DTMRI,this study aimed to explore the primary models of white matter changes of SZ patients at different disease stages so as to provide references for clinical diagnosis and treatment.