摘要
目的分析慢性精神分裂症患者血清同型半胱氨酸（Hcy）、血脂水平,探讨Hcy、血脂水平与认知功能之间的关系。方法分别测定154例慢性精神分裂症患者、60名健康志愿者（正常对照组）的Hcy、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。将慢性精神分裂症患者根据蒙特利尔认知评估量表（MoCA）评估结果分为认知障碍组和无认知障碍组,并对结果进行统计分析。结果认知障碍组Hcy、TC、TG、LDL-C水平均高于无认知障碍组和正常对照组（P均〈0.05）,HDL-C水平低于正常对照组（P〈0.05）。单因素Logistic回归分析表明,Hcy、TC、TG、LDL-C是慢性精神分裂症患者认知损害的危险因素[比值比（OR）分别为1.114、1.791、2.141、1.556,95%可信区间（CI）分别为1.034~1.200、1.237~2.593、1.263~3.630、1.091~2.217]。多因素Logistic回归分析表明,Hcy是慢性精神分裂症患者认知损害的独立危险因素（OR=1.125,95%CI为1.040~1.217）。慢性精神分裂症患者血清Hcy水平与MoCA评分呈负相关（r=-0.362,P=0.000）。结论慢性精神分裂症患者的认知损害可能与血清Hcy水平升高和脂代谢异常有一定的关系。
Objective To determine serum homocysteine（ Hcy） and blood lipid,and to investigate the relationships of Hcy and blood lipid with cognitive function in patients with chronic schizophrenia. Methods The levels of Hcy,total cholesterol（ TC）, triglyceride（ TG）, high-density lipoprotein cholesterol（ HDL-C） and low-density lipoprotein cholesterol（ LDL-C） were determined in 154 patients with chronic schizophrenia and 60 healthy subjects（ healthy control group）. The patients with chronic schizophrenia were classified into cognitive impairment group and non-cognitive impairment group according to the assessment of Montreal Cognitive Assessment（ Mo CA）. The results were analyzed statistically. Results In cognitive impairment group,the levels of Hcy,TC,TG and LDL-C were significantly higher than those in non-cognitive impairment group and healthy control group（ P 〈 0. 05）,and the level of HDL-C was lower than that in healthy control group（ P 〈 0. 05）. Univariate Logistic regression analysis showed that Hcy,TC,TG and LDLC were risk factors for cognitive impairment in patients with chronic schizophrenia [odds ratios（ OR） were 1. 114,1. 791,2. 141 and 1. 556; 95% confidence intervals（ CI） were 1. 034-1. 200,1. 237-2. 593,1. 263-3. 630 and 1. 091-2. 217]. Multivariate Logistic regression analysis showed that only Hcy was an independent risk factor for cognitive impairment in patients with chronic schizophrenia（ OR = 1. 125,95% CI was 1. 040-1. 217）. Serum Hcy had negative correlation with Mo CA score in patients with chronic schizophrenia（ r =- 0. 362,P = 0. 000）. Conclusions Cognitive impairment in patients with chronic schizophrenia may be associated with abnormal metabolism of Hcy and blood lipid.
出处
《检验医学》
CAS
2015年第12期1198-1202,共5页
Laboratory Medicine
基金
国家自然科学基金资助项目(81301159)
上海市卫生系统优秀学科带头人培养计划(XBR2013087)
上海市医学重点专科建设项目(ZK2012A12)
上海市虹口区卫计委科研课题(虹卫1304-47)
