米诺环素联合红蓝光治疗面部中、重度痤疮疗效观察及分析

Observation of minocycline combined with the red and blue light on the curative effect of treatment of moderate and severe acne

目的:观察米诺环素联合红蓝光治疗中、重度痤疮的疗效及不良反应。方法:将符合要求的60例中、重度痤疮患者按照就诊的先后顺序,采取随机数字表法分为红蓝光组和米诺环素联合红蓝光组,每组各30例。红蓝光组:采用红蓝光照射治疗,20min/次,2次/周;米诺环素联合红蓝光组:在上述治疗基础上,给予口服米诺环素100mg,每天2次。两组治疗时间均为4周,观察皮损的变化情况及不良反应。结果:红蓝光组总有效率为43.3%,其中Ⅲ级、Ⅳ级患者的痊愈及显效率为30.0%;米诺环素联合红蓝光组总有效率为76.6%,其中Ⅲ级、Ⅳ级患者的痊愈及显效率为71.4%。与红蓝光组比较,米诺环素联合红蓝光组的总有效率和Ⅲ级、Ⅳ级患者的痊愈及显效率有显著性差异(P<0.01)。两组不良反应均能耐受,不影响后续治疗,两组之间无明显差异(P>0.05)。结论:米诺环素联合红蓝光治疗中、重度痤疮是一种安全、有效的治疗方法,值得临床广泛应用。

Objective Observation of minocycline combined with the red and blue light on the curative effect and the adverse reactions of the treatment of moderate and severe acne.Methods To comply with the requirements in 60 cases of patients with severe acne,according to the sequence of treatment,take random number table method,divided into red and blue light group,minocycline combined with red and blue light group,30 cases in each group.Red and blue light group with red and blue light irradiation,20 minutes each time,2 times/W;minocycline combined with red and blue light group,on the basis of the above treatment,treated with minocycline 100 mg bid,Po.The treatment time of the two groups was 4 weeks.To observe the changes of skin lesions and adverse reactions.Results Red and blue group total effective rate was 43.3%,the grade III and IV patients cured and markedly effective rate was 30%;minocycline with red and blue group the total efficiency was 76.6%,the grade III and IV patients cured and markedly effective rate was 71.4%.Compared with red and blue light group,minocycline with red and blue group the total efficiency and grade III and IV patients of recovery and significant efficiency had significant difference（P〈0.01）.The adverse reactions of the two groups were able to withstand,without affecting the follow-up treatment,there was no significant difference between the two groups（P〉0.05）.Conclusion Minocycline combined with red and blue light in the treatment of moderate to severe acne is a safe and effective treatment,worthy of clinical application.