放射治疗同步TNF方案治疗晚期鼻咽癌的疗效分析

Analysis of efficacy of radiation therapy in treatment of TNF synchronous advanced nasopharyngeal carcinoma

目的研究分析放射治疗同步TNF(紫杉醇+氟尿嘧啶+奈达铂)方案治疗晚期鼻咽癌的疗效和毒副反应。方法 136例晚期鼻咽癌患者随机分为治疗组68例(放射治疗同步TNF方案化疗)和对照组(单纯放射治疗)68例。治疗组在放射治疗的第1、4周分别给予TNF方案化疗和放射治疗结束后给予2个周期TNF方案化疗。结果研究结果表明:治疗组的近期疗效为:治疗组有效率为97.01%(66/68),对照组有效率为76.47%(52/68),两组有统计学差异(P<0.05)。治疗组1、3年生存率为94.12%和85.29%,对照组1、3年生存率为70.59%和47.06%,差异有统计学意义(P<0.05)。治疗组骨髓抑制、消化道反应发生率为32.35%、36.76%,对照组骨髓抑制、消化道反应发生率为20.59%、23.53%,治疗组骨髓抑制及消化道反应虽然较对照组高,但和对照组比较无统计学差异。结论放射治疗同步TNF方案化疗能提高晚期鼻咽癌的疗效且不增加不良反应。

Objective To analyze the effect of synchronous radiotherapy TNF（ paclitaxel ＋ fluorouracil ＋ Nedaplatin）in the treatment of patients with advanced nasopharyngeal carcinoma and toxicity. Methods Totally 136 cases of advanced nasopharyngeal carcinoma were randomly divided into treatment group of 68 patients（ TNF synchronous radiotherapy regimen） and control group（ radiotherapy alone） 68 cases. TNF treatment group were given 1,4- week program in radiation therapy and chemotherapy and radiation therapy given after the end of two cycles of chemotherapy with TNF.Results The results show that： short- term effect of the treatment group： the treatment group was 97. 01%（ 66 /68）,in the control group was 76. 47%（ 52 /68）,the two groups were significantly different（ P〈0. 05）. Treatment group,3- year survival rate was 94. 12% and 85. 29% in the control group,3- year survival rate was 70. 59% and 47. 06%,the difference was statistically significant（ P〈0. 05）. Treatment of bone marrow suppression,gastrointestinal reactions was 32. 35%,36. 76% in the control group of bone marrow suppression,gastrointestinal reactions was 20. 59%,23. 53% in the treatment group,although myelosuppression and gastrointestinal reactions than the control group,but there was no significant difference in the control group. Conclusion TNF synchronous radiotherapy can improve the efficacy of chemotherapy in advanced nasopharyngeal carcinoma without increasing side effects.