哌拉西林舒巴坦罕见过敏反应1例报道及分析

Rare allergic reactioninduced by piperacillin-sulbactam compound preparation——a case report

目的:分析并探讨本院1例哌拉西林舒巴坦导致的罕见过敏反应发生的原因,为临床用药提供参考。方法:报道1例哌拉西林舒巴坦所致的眼部水肿、充血反应,同时对近8年来文献所报道的哌拉西林及其复方制剂的不良反应进行分析,通过临床表现和文献分析推测不良反应发生的原因。结果:哌拉西林舒巴坦所致的眼部水肿、充血可能是由过敏反应导致。通过文献分析发现,过敏反应是哌拉西林及其复方制剂最常见的不良反应,且往往在皮试反应阴性的情况下发生,假阴性的发生与皮试液配制关系密切。结论:为提高用药安全性,有必要对皮试液及配制方法进行改进和规范,同时注意对患者的监护。

Objective： To report a rare allergic reaction induced by piperacillin and sulbactam compound preparation and explore the reasons for it,providing a reference for clinical rational drug use. Methods： Ocular edema and congestion was observed after administration of piperacillin and sulbactam compound preparation in our hospital. We retrieved relevant literature through CNKI database to know about similar ADR and the reasons for it. Results： Ocular edema and congestion induced by piperacillin and sulbactam was believed to be an allergic reaction. Literature disclosed that this ADR happened with the most frequency with piperacillin and its compound preparations and usually occurred in patients with a negative skin- test result. False- negative result has something to do with the preparation of skin- test solution. Conclusions： For improving safety of drug use,skin- test reagent and its preparation needs to be modified and patients must be monitored properly.