深圳西北部地区儿童住院患者巨细胞病毒感染调查

Investigation into cytomegalovirus infection of hospitalized children in the northwest areas of Shenzhen

目的调查深圳市西北部儿童住院患者巨细胞病毒感染现状。方法 2013-07/2015-06对深圳市西北部宝安区福永人民医院、宝安区松岗人民医院、光明新区人民医院3家医院收治5 245例巨细胞病毒感染疑似住院患儿进行CMV感染调查,留取血液标本进行CMV-IgG与CMV-IgM抗体检测。结果5 245例疑似巨细胞病毒感染住院患儿中共733例确诊为巨细胞病毒感染,感染率为14.0%(733/5 245)。其中37.5%(275/733)为原发性感染,62.5%(458/733)为活动性感染。黄疸、肝功能损害、肺炎、血液系统等临床表现发生率存在一定差异,两两比较差异有统计学意义(P<0.05)。733例感染患儿中,女童感染者明显高于男童,两者比较差异有统计学意义(P<0.05)。结论深圳西北部地区儿童住院患者巨细胞病毒感染率在14.0%左右,女童感染率高于男童,且随年龄不同主要临床表现存在差异。

Objective To investigate the current situation of cytomegalovirus infection of hospitalized children in the northwest areas of the city.Methods Totally 5245 cases of children with suspected cytomegalovirus infection admitted to Fuyong People＇s Hospital of Baoan District,Songgang People＇s Hospital of Baoan District,and People＇s Hospital of Guangming New District in the northwest areas of the city from July 2013 to June 2015 were investigated by CMV infection survey.Blood specimens were taken to perform CMV-IgG and CMV-IgM antibody detection.Results Among the 5245 cases of hospitalized children with suspected cytomegalovirus infection,there were 733 cases confirmed with cytomegalovirus infection and the infection rate was 14.0%（733/5245）,of which 37.5%（275/733）was primary infection and 62.5%（458/733）was active infection.There were certain differences in the incidence rates of clinical manifestations,such as jaundice,liver function damage,pneumonia and blood system and the differences were statistically significant（P〈0.05）.In 733 cases of infected children,the infected female was significantly more than the infected male（P〈0.05）.Conclusion The infection rate of cytomegalovirus infection in hospitalized children in the northwest areas of Shenzhen is about 14.0%.The infection rate of the female is higher than that of the male and the main clinical manifestations are different in patients of different age.