摘要
运用THz-TDS技术和Far-FTIR技术在干燥氮气和真空环境下分别测量了阿奇霉素干混悬剂、胶囊、片剂、分散片等不同物理形态的药品在0.2~5.0THz波段的光谱。其中,阿奇霉素干混悬剂在0.2~15.0THz波段内存在较为明显的吸收峰,且对比国产和进口产品的特征峰可以发现,国产药品在几个主峰上都表现出谱线增宽,且有部分多余小峰出现,可能是由于结晶度不纯和杂质引起的。而国产阿奇霉素胶囊、片剂、分散片则由于填充辅料、样品颗粒较大、样品含量少等原因致使吸收基线随频率增高而上扬,上述特征峰在0.2~2.7THz波段发生不同程度的变弱和频移。同时,对不同浓度进口阿奇酶素干混悬剂与聚乙烯的混合物作了分析,根据浓度与吸收强度呈现的线性正相关关系,可以较为准确地分析出有效成分的浓度,从而实现对阿奇霉素类混合体系药品的质量检测和评估。
Far Fourier transform infrared spectroscopy(Far-FTIR)and terahertz time-domain spectroscopy(THz-TDS)were used to measure the fingerprint spectra of Azitromycin suspension,capsule,tablet and dispersible tablet under vacuum and nitrogen conditions,respectively.In the frequency range of 0.2~15THz,highly resolved spectral features for Azitromycin suspension were measured and some minor differences were observed between domestic and exotic Azitromycin Suspension,such as linewidth broadening and additional peaks.As same time,for the domestic Azitromycin capsule,tablet and dispersible tablet,the absorption baselines in the range of 0.2~2.7THz rise with the increase of frequency while absorption peaks become weaker due to the scattering of bigger particles and smaller amount of Azitromycin.Also,the additional peaks are caused by the absorption of filling materials.In parallel with the qualitative measurement,the THz absorption spectra for mixtures of polyethylene(PE)powders and exotic Azithomycin suspension with different concentrations were also measured.According to the linear correlation between the concentration and the absorption intensity,the concentration of effective component can be evaluated accurately.This means that THz-TDS method is suitable for the quality inspection and evaluation of the mixed Azithromycin system.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2015年第11期3054-3057,共4页
Spectroscopy and Spectral Analysis
基金
国家自然科学基金项目(11104360,11204191,11374378)
国家重大科学仪器设备开发专项项目(2012YQ14000508)
留学人员科技活动择优项目
国家民委“光传感与光子系统集成”创新团队
国家大学生创新性试验计划项目(GCCX2014110002)资助
关键词
太赫兹光谱
远红外光谱
阿奇霉素
Terahertz Time-domain spectroscopy
Far-FTIR
Azitromycin