A Short Synthesis of Clionamine D
A Short Synthesis of Clionamine D
摘要
Herein we describe a scalable four-step preparation of a-methylene-y-lactone 3 from steroidal sapogenin. This method allowed a facile synthesis of clionamine D, a natural aminosteroid with potent autophagy bioactivity and unprecedented chemical structure.
Herein we describe a scalable four-step preparation of a-methylene-y-lactone 3 from steroidal sapogenin. This method allowed a facile synthesis of clionamine D, a natural aminosteroid with potent autophagy bioactivity and unprecedented chemical structure.
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