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介孔二氧化硅纳米复合材料医学应用的研究进展

Recent progress on the medical applications of mesoporous silica composite
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摘要 介孔二氧化硅复合材料是一种新型的无机纳米生物材料。因为其巨大的比表面积和良好的表面活性,具有很大的药容量,良好的生物相容性、低毒性和易加工修饰等特点。介孔二氧化硅在进行修饰和改造之后,在长时、可控、靶向的药物传输系统的建立和改善方面显示出许多优势。本篇综述将介绍MSNs的生物性质、制备和修饰、载药行为和动物实验研究。 Mesoporous silica nanoparticles is a new kind of nanosized biomaterials. Because of the large specific surface area and unique surface properties, mesoporous silica nanoparticles have a superiority in drug capacity, biocompatibility, low toxicity and functionalization. After the modification, this material is used to develop and improve the sustained, controllable and targeted drug delivery system. This review will introduce the biological characters, preparation, modification, drug delivery behavior and animal experimental study of mesoporous silica nanoparticles
作者 张郑 陈晓 翁蔚宗 曹烈虎 苏佳灿
机构地区 上海长海医院创伤骨科
出处 《世界复合医学》 2015年第4期330-335,共6页 World Journal of Complex Medicine
基金 国家自然科学基金(31271031) 国家自然科学基金国际重大合作项目(8141101156) 上海市科学技术委员会基础重点项目(11JC14163020)
关键词 介孔二氧化硅 载体 生物特性 药物传输 综述 Mesoporous Silica Nanoparticles Carrier Biological Characters Drug Delivery Review
分类号 TB34 [一般工业技术—材料科学与工程]
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参考文献38

  • 1Swami A, Jinjun S, Suresh G, et al. Nanoparticles for targeted and temporally controlled drug delivery. [M] Multifunctional Nanoparticles for Drug Delivery, Applications: Imaging, Targeting, and Delivery, Nanostructure Science Technology. Bostan, USA: Springer; 2012. pp. 9-25.
  • 2Kresge CT, Leonowicz ME, Roth WJ. Ordered mesoporous molecular sieves synthesized by a liquid-crystal Template mechanism [J]. Nature,359( 6397):710-712.
  • 3Sooyeon K, Singh RK, Wojciech C. Silica-based mesoporous nanoparticles for controlled drug delivery [J]. J Tissue Eng, 2013,4(10):1-35.
  • 4Brannon-Peppas L. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery [J]. Int J Pharm, 1995, 116(1): 1-9.
  • 5Shchipunov VA, Burtseva YV, Karpenko TY, et al. Highly efficient immobilization of endo-l, 3-beta-d-glucanases (laminarinases) from marine mollusks in novel hybrid polysaccharide-silica nanocomposites with regulated composition [J]. J Mol Catal, 2006, 40(1-2):16-23.
  • 6Klichko Y, Liong M, Choi E, et a1.Mesostructured Silica for Optical Functionality, N anomachines, and Drug Delivery [J]. JAm Ceram Soc, 2009, 92(1):2-10.
  • 7Tourne-Peteilh C, Begu S, Lerner DA, Get al. Sol-gel one?pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system [J]. J Solgel Sci Technol, 2012, 61(3):455-62.
  • 8Fruijtier-Polloth C. The toxicological mode of action and the safety of synthetic amorphous silica-a nanostructured material [J]. Toxicology, 2012, 294(2-3):61-79.
  • 9Liong M, Lu J, Kovochich M, et al. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery [J]. ACS Nano, 2008,2(5):889-96.
  • 10Russo R E, Hunt A J .Comparison of Ethyl Versus Methyl Sol Gels for Silica Aerogels Using Polar Nephelometry [J]. J Non-Crys Solids, 1986, 86(1-2):219-231.

二级参考文献33

  • 1Beck J S,Vartuli J C,Roth W J,et al.A new family of mesoporous molecular sieves prepared with liquid crystal templates[J].J Am Chem Soc,1992,114(27):10834.
  • 2Zhao D,Feng J,Huo Q,et al.Triblock copolymersyntheses of mesoporous silica with periodic 50 to 300 angstrom pores[J].Science,1998,279(5350):548.
  • 3Wan Y,Shi Y,Zhao D.Designed synthesis of mesoporous solids via nonionic-surfactant-templating approach[J].Chem Commun,2007(9):897.
  • 4Che S A,Garcia-Bennett A E,Yokoi T,et al.Mesoporous silica of novel structures with periodic modulations synthesized by anionic surfactant templating route[J].Nature Mater,2003,2:801.
  • 5Firouzi A,Kumar D,Bull L M,et al.Cooperative organization of inorganic-surfactant and biomimetic assemblies[J].Science,1995,267(5201):1138.
  • 6Yoon S B,Kim J Y,KimJ H,et al.Template synthesis of nanostructured silica with hollow core and mesoporous shell structures[J].Curr Appl Phys,2006,6:1059.
  • 7Wan Y,Yu S H.Polyelectrolyte controlled large-scale synthesis of hollow silica spheres with tunable sizes and wall thicknesses[J].J Phys Chem C,2008,112:3641.
  • 8Zhang T R,Ge J P,Hu Y X,et al.Formation of hollow silica colloids through a spontaneous dissolution-regrowth process[J].Angew Chem,2008,120(31):5890.
  • 9Hu Y X,Ge J P,Sun Y G,et al.A self-templated approach to TiO2 microcapsules[J].Nano Lett,2007,7(6):1832.
  • 10Yin Y D,Rioux R M,Erdonmez C K,et al.Formation of hollow nanocrystals through the nanoscale Kirkendall effect[J].Science,2004,304(5671):711.

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世界复合医学
2015年 第4期

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