老年肺心病急性期患者免疫功能的分析

Changes of T lymphocyte subgroups in acute and recession period of aged cor pulmonale patients

目的:研究老年肺心病患者T淋巴细胞亚群的变化,并探讨其与急性期和缓解期的关系。方法:用CD系列抗人T淋巴细胞克隆抗体和流式细胞仪技术测定40例老年肺心病急性期和缓解期患者外周血T淋巴细胞亚群,并与22例老年健康对照组作比较。结果:老年肺心病急性期CD4/CD8低于老年健康对照组（1.16±0.53:1.43±0.25,P<0.05）;缓解期CD4/CD8（1.36±0.45）高于急性期组（1.16±0.53,P<0.05）。结论:老年肺心病患者在急性期免疫功能降低,随着病情的缓解免疫功能得到改善。

Objective: To explore the changes of T lymphocyte subgroups in acute or recession period of aged cor pulmonale patients. Methods: T lymphocyte subgroups in 40 aged cor pulmonale patients assayed with flow cytometry technique and CD series of monoclonal antibodies of human T lymphocytes. Twenty-two healthy aged persons were used as controls. Results: CD4/CD8 in aged cor pulmonale patients was lower than those of aged controls (1. 16±0. 53 :1. 43±0. 25. P<0. 05). CD4/CD8 in remission period of cor pulmonale was higher than that in acute period (1. 36±0. 45: 1. 16±0. 53,P<0. 05). Conclusion:For the aged cor pulmonale patients the immunological function decrease in acute period and improve in remission period.