COPD患者活动耐力和肺动脉收缩压的相关性分析

Correlation analysis between activity endurance and pulmonary arterial systolic pressure in COPD patients

目的分析稳定期慢性阻塞性肺疾病(COPD)患者进行六分钟步行试验(6MWT)与动脉血气指标、肺通气功能指标、肺动脉收缩压(s PAP)的相关性,探讨影响COPD患者活动耐力的相关因素。方法 60例COPD稳定患者根据六分钟步行距离(6MWD)分为A组(18例)、B组(21例)、C组(21例),分析肺通气功能参数、动脉血气参数、s PAP与6MWD的关系。结果三组一秒用力呼气容积(FEV1)和FEV1占预计值百分比(FEV1%pred)、氧分压(Pa O2)、s PAP比较差异有统计学意义(P<0.05),进行多元逐步回归分析,其对6MWD影响的独立相关因素按其重要性依次为s PAP、FEV1、FEV1%pred。结论 s PAP对COPD患者的活动耐力影响最大。6MWD可作为对COPD患者长期监测的一种手段,可对COPD患者病情的评价进行有效补充。

Objective To analyze correlation between six-minute walking test（6MWT） and their arterial blood gas index, pulmonary ventilation function index, and pulmonary arterial systolic pressure（s PAP） in stable stage chronic obstructive pulmonary disease（COPD） patients, and to investigate related influencing factors of activity endurance in COPD patients. Methods A total of 60 stable stage COPD patients were divided by six-minute walking test distance（6MWD） into group A（18 cases）, group B（21 cases） and group C（21 cases）. Relationship of pulmonary ventilation function index, arterial blood gas index, s PAP, and 6MWD was analyzed. Results The difference of forced expiratory volume in one second（FEV1）, FEV1 percentage predicted（FEV1%pred）, arterial partial pressure of oxygen（Pa O2）, and s PAP had statistical significance in the three groups（P〈0.05）. Multiple stepwise regression analysis showed independent influencing factors of 6MWD were respectively s PAP, FEV1 and FEV1%pred. Conclusion s PAP has the largest influence on activity endurance in COPD patients. As a long-term monitoring measure for COPD patients, 6MWD can provide effective supplement to evaluation of COPD status in patients.