p21^(WAF1)的调节——乙酰化和甲基化
被引量：1
Regulation of P21waf1——acetylation and methylation
摘要
近来研究认为下调转录的DNA启动子区甲基化和使染色质功能下降的组蛋白乙酰化是p2 1WAF1失活的重要机制。现综述组蛋白乙酰化和DNA甲基化对 p2 1WAF1转录的影响 ,以及与之有关的影响途径或因素。
出处
《国外医学（肿瘤学分册）》
2002年第4期263-266,共4页
Foreign Medical Sciences (Cancer Section)
参考文献23
-
1Elledge SJ, Winston J, Harper JW. A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis[J]. Trends Cell Biol, 1996, 6(3): 388-392.
-
2Shin JY, Kim HS, Park J, et al. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells[J]. Cancer Res, 2000, 60(2): 262-265.
-
3Baylin SB, Herman JG, Graff JR, et al. Alterations in DNA methylation: a fundamental aspect of neoplasia[J]. Adv Cancer Res, 1998, 72(1): 141-196.
-
4Struhl K. Histone acetylation and transcriptional regulatory mechanism[J]. Genes Dev, 1998, 12(5): 599-606.
-
5Xiao H, Hasegawa T, Isobe KI. p300 collaborates with Spl and Sp3 in p21WAF1 promoter activation induced by histone deacetylase inhibitor[J]. J Biol Chem, 2000, 275(2): 1371-1376.
-
6Xiao H, Hasegawa T, Isobe KI. Both spl and sp3 are responsible for p21WAF1 promoter activity induced by histone deacetylase inhibitor in HIH3t3 cells[J]. J Cell Biochem, 1999, 73(3): 291-302.
-
7Sambucetti LC, Fischer DD, Zabludoff S, et al. Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects[J]. J Biol Chem, 1999, 274(49): 34940-34947.
-
8Archer SY, Hodin RA. Histone acetylation and cancer[J]. Curt Opin Genet Dev, 1999, 9(2): 171-174.
-
9Siavoshian S, Segain JP, Komprobst M, et al. Butyrate and trichostain A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression[J]. Gut, 2000, 46(4): 507-514.
-
10Kim JS, Lee S, Lee YW, et al. Transcriptional activation of p21WFA1 by apicidin, a novel histione deacetylase inhibitor[J]. BiocheM Biophys Res Commun, 2001, 281(4): 866-871.
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-
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-
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-
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-
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-
5Zou XM, Li YL, Wang H, Cui W, Li XL, Fu SB, Jiang HC. Gastric cancer cell lines induced by trichostatin A. World J Gastroenterol 2008; 14:4810-4815.
-
6Dhordain P, Lin RJ, Quief S, Lantoine D, Kerckaert JP, Evans RM, Albagli O. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. Nucleic Acids Res 1998; 26:4645-4651.
-
7Marks PA, Richon VM, Breslow R, Rifkind RA.Histone deacetylase inhibitors as new cancer drugs. Curr Opin Oncol 2001; 13:477-483.
-
8Duan H, Heckman CA, Boxer LM. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Bio12005; 25:1608-1619.
-
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-
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