摘要
目的:了解莫西沙星致老年患者药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:采用回顾性调查法,对2014年度北京市ADR监测中心接收的莫西沙星所致的老年患者ADR报告数据按照年龄、性别、给药途径、合并用药情况、ADR主要临床表现等进行统计、分析。结果:293例ADR中,以男性居多(55.63%),70~79岁老年患者发生ADR较多(35.84%);临床表现多为皮肤及其附件损害(30.07%)、中枢及外周神经系统损害(27.68%)、心血管系统损害(13.37%)和胃肠系统损害(10.74%),其中以皮疹、瘙痒、头晕、心悸、恶心等最为显著;ADR发生时间多在24 h以内(56.31%);静脉给药ADR发生率远大于口服给药发生率(92.15%vs.7.85%)。严重ADR 16例,其中死亡2例。结论:临床应重视莫西沙星在老年患者中引起的ADR,警惕严重ADR的发生。
OBJECTIVE:To investigate the characteristics and clinical manifestations of adverse drug reaction(ADR)related to moxifloxacin on elderly patients,and provide references for clinical drug.METHODS:Moxifloxacin-induced ADR reports of elderly patients collected by Beijing ADR Monitoring Center in 2012 were analyzed statistically.RESULTS:Among 293 ADR cases,there were a majority of male patients(55.63%),mainly aged 70-79 years old(35.84%);main clinical manifestations were lesion of skin and its appendants(30.07%),nervous system reaction(27.68%),circulatory system damage(13.37%)and gastrointestinal system reaction(10.74%),especially rash,pruritus,palpitation,nausea,psychogeny,phlebitis.Most ADRs occurred within24 h(56.31%).The incidence of ADR induced by intravenous administration was significantly higher than that of oral administration(92.15% vs.7.85%).There were 16 cases of severe ADR.CONCLUSIONS:Great importance should be attached to the ADR induced by moxifloxacin in the elderly and the occurrence of serious ADR.
出处
《中国药房》
CAS
北大核心
2016年第2期201-204,共4页
China Pharmacy