摘要
目的探讨^(18)F-FDG PET/CT在弥漫大B细胞淋巴瘤(DLBCL)免疫亚型诊断中的应用价值。方法回顾性分析69例在本院初诊DLBCL患者的^(18)F-FDG PET/CT表现。观察生发中心B细胞样(GCB)和非生发中心(non-GCB)的^(18)F-FDG PET/CT表现特征;分析不同免疫亚型PET/CT影像指标[标准化摄取最大值(SUV_(max))、病灶数]、临床特征(Ann Arbor分期、临床症状、性别、年龄)及核抗原Ki-67的差异。结果 ^(18)F-FDG PET/CT显示,单发病灶12例(12/69,17.39%),多发病灶57例(57/69,82.61%)。DLBCL病灶SUVmax为11.80(8.80)。不同免疫亚型的病灶SUV_(max)(Z=-0.03)、Ki-67(t=0.03)、PET/CT病灶数(χ~2=0.06)、Ann Arbor分期(χ2=3.48)、临床症状(χ~2=0.49)、性别(χ~2=1.62)、年龄(r=-0.21)比较,差异均无统计学意义(P均>0.05)。SUV_(max)与Ki-67呈正相关(r=0.38,P<0.05)。结论 ^(18)F-FDG SUV_(max)可预测DLBCL的增殖情况及侵袭程度。
Objective To evaluate the application value of ^18F-FDG PET/CT in diffuse large B-cell lymphoma（DLBCL）immunological subtyping.Methods Sixty-nine patients who underwent ^18F-FDG PET/CT imaging for newly diagnosed DLBCL were retrospectively reviewed.The ^18F-FDG PET/CT imaging performances of germinal center B-cell like（GCB）and non-GCB immunological subtypes were observed.The difference of immunological subtypes with PET/CT imaging indexes（maximum of standard uptake value[SUV_（max）],lesion numbers）,clinical characteristics（Ann Arbor stage,clinical symptoms,gender,age）,and Ki-67 was analyzed,respectively.Results Twelve cases（12/69,17.39%）were presented with single lesion,and fifty-seven cases（57/69,82.61%）were multiple lesions.SUV_（max） of DLBCL lesions was 11.80（8.80）.In different immunological subtypes,in SUV_（max）（Z=-0.03）,Ki-67（t=0.03）,PET/CT lesion numbers（χ2=0.06）,Ann Arbor stage（χ2=3.48）,clinical symptoms（χ2=0.49）,gender（χ2=1.62）,and age（r=-0.21）had not any statistical difference（all P〉0.05）.Significantly positive correlation of SUV_（max）and Ki-67 was observed（r=0.38,P〈0.05）.Conclusion ^18F-FDG SUV_（max）can predict the proliferation condition and invasive degree of DLBCL.
出处
《中国医学影像技术》
CSCD
北大核心
2016年第1期75-78,共4页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(NSFC30900374
81071183)
