摘要
目的探讨Podoplanin在肝细胞癌组织中的表达及与淋巴管转移的关系。方法选取2003年1月～2014年1月在大庆油田总医院和齐齐哈尔医学院病理中心手术切除并病理证明为肝细胞癌的标本存档蜡块53例为研究对象，有淋巴结转移35例，无淋巴结转移18例。其中肝细胞癌组织35例，癌旁组织35例，另选正常肝组织9例，采用免疫组化检测Podoplanin的阳性表达，观察Podoplanin在肝细胞癌组织、癌旁组织、正常肝组织中的表达情况，分析Podoplanin的阳性表达与肝细胞癌淋巴管转移的关系。结果Podoplanin在肝细胞癌组织中高表达，在正常肝组织中低表达（P〈0．05）。Podoplanin阳性表达在肝细胞癌淋巴管转移中明显高于无淋巴管转移（P〈0．05）。结论Podoplanin在肝细胞癌中高表达可能与淋巴管生成和淋巴管转移密切相关。
Objective To disscuss relationship between the expression of Podoplanin and lymphatic metastasis in hepatocellular carcinoma. Methods 53 cases of archival paraffin block with hepatoeellular carcinoma were selected as study objects in Daqing Oilfield General Hospital and Pathology Center of Qiqihar Medical College from January 2003 to January 2014. 35 cases were lymph node metastasis and 18 cases were no lymph node metastasis. 35 cases were hepatoma tissues, 35 cases were adjacent tissues and 9 cases were normal liver tissues. Immunohistochemistry was used to detect the positive expressions of Podoplanin, and the expressions of Podoplanin in hepatoma tissues, adjacent tissues and normal liver tissues were observed. The relationship between the positive expression of Podoplanin and hepatocellular carcinoma with lymph metastasis was analyzed. Results Podoplanin was high expressed in hepatoma tissues, while was low expressed in normal liver tissues （P 〈 0.05）. Podoplanin was higher expressed in lymph node metastasis than that in no lymph node metastasis （P 〈 0.05）. Conclusion The high expression of Podoplanin in hepatoeellular carcinoma should have close relationship with lymphatic genesis and lymphatic metastasis.
出处
《中国医药导报》
CAS
2016年第2期78-80,共3页
China Medical Herald
基金
黑龙江省教育厅课题(12531831)
