脑淀粉样变性相关炎症反应的研究进展

Recent advance in cerebral amyloid angiopathy related inflammation

脑淀粉样血管病变（CAA）是一种老年人常见的颅内微血管病变，主要病理特征是β淀粉样蛋白（Aβ）在大脑皮层及皮层下、软脑膜中及小血管的中外膜沉积。脑淀粉样变性相关炎症反应是最近公认的发生在一部分脑淀粉样变性患者中的可逆性的脑病。本文就脑淀粉样变性相关炎症反应的病理机制、临床表现及进程、相关辅助检查、诊断及鉴别诊断和治疗方面的最新进展进行综述。

Cerebral amyloid angiopathy （CAA） is a disorder characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and it is one of the common cerebral vascular diseases in the elderly. Cerebral amyloid angiopathy related inflammation （CAA-I）, is a recently recognized syndrome of reversible encephalopathy seen in a subset of patients with CAA. Here, we review the advances in research on the pathological mechanism, clinical features and course, investigations, diagnosis and differential diagnosis, and treatment of CAA-I.