伏马菌素的毒性及其作用机理

Toxicity and mechanism of Fumonisins

伏马菌素是主要由串珠镰刀菌和再育镰刀菌代谢产生的一类真菌毒素,其对农作物的污染在世界范围内普遍存在,尤其是玉米及玉米制品。在目前发现的多种伏马菌素中,伏马菌素B1是主要组分,且其毒性最大。本研究介绍了伏马菌素的化学结构、产毒菌株及在动物体内的代谢情况,着重概述了伏马菌素的毒性及其作用机理,并对今后如何减轻伏马菌素对人和动物的危害进行了探讨和展望。

Fumonisins are one kind of mycotoxin,mainly produced by Fusarium vertieilliodes and Fu sarium proliferatum. Crops contamination by Fumonisins is worldwide, especially for maize and maize products. Currently,Fumonisin B1 （FB1） is the main species among discovered Fumonisins with the largest toxicity. This paper briefly describes the chemical structure of Fumonisins, toxigenic strains and metabolism in animals,with the focuses on toxicity and mechanism. Discussion and outlook on how to reduce harm of Fumonisins to humans and animals are also presented.