麻醉深度监测对全身麻醉恢复时间影响的Meta分析

Meta-analysis of effect of the anesthesia depth monitoring on anesthesia recovery time with general anesthesia

目的分析评价全身麻醉手术中麻醉深度监测对患者术毕麻醉恢复情况的影响。方法计算机检索中国知网、万方、维普、Cochrane图书馆、PubMed等数据库,收集应用麻醉深度监测,如听觉诱发电位指数(AAI)或脑电双频指数(BIS),或未应用麻醉深度监测的临床随机对照研究。对纳入文献进行质量评价及数据提取,采用RevMan 5.0软件进行Meta分析,观察患者术毕麻醉恢复情况。结果共纳入11项临床随机对照研究,受试者743例。在全身麻醉中,应用AAI监测或BIS监测时患者术毕睁眼时间、拔管时间、定向力恢复时间均较未应用任何麻醉深度监测者明显缩短(P<0.05);应用AAI监测者与应用BIS监测者比较,睁眼时间、拔管时间、定向力恢复时间比较,差异无统计学差异(P>0.05)。结论全身麻醉中应用麻醉深度监测,可以缩短麻醉结束后睁眼时间、拔管时间与定向力恢复时间。应用AAI监测与BIS监测麻醉深度对患者术毕麻醉恢复情况的影响相当。

Objective To analyze the influence of anesthesia depth monitoring during general anesthesia surgery on the recovery time after the operation.Methods A systematic search was performed in CNKI,Wanfang,VIP,PubMed,randomized controlled trials（RCT） about application or un-application of anesthetic depth monitoring after the operation,such as auditory evoked potential index（AAI） and bispectral index（BIS） were collected.The quality of studies was assessed and data was extracted,Meta-analysis was performed by the using of RevMan 5.0 software,the clinical impact of the anesthesia recovery time by the conducting of anesthesia depth monitoring was observed.Results A total of 743 subjects in 11 RCTs were included in this study.According to the results,there was an obviously reducing in the eye opening time,extubation time and orientation recovery time in patients with AAI or BIS monitoring during general anesthesia,compared with those without any anesthetic depth monitoring（P〈0.05）.Nevertheless,there was no statistically significant difference in eye opening time,extubation time and orientation recovery time between patients with AAI monitoring and patients with BIS monitoring（P〉0.05）.Conclusion Anesthesia depth monitoring in general anesthesia can decrease the eye opening time,extubation time and orientation recovery time.There has equal effect on between AAI monitoring and BIS of depth monitoring of anesthesia reducing for the anesthesia recovery time in general anesthesia.