HPLC法检测结核性胸膜炎患者血清和胸液中异烟肼浓度

Determination of isoniazid concentration of serum and hydrothorax of patients with tuberculous pleurisy by HPLC

目的 :探讨药物浓度对治疗结核性胸膜炎的意义。方法 :采用高效液相法检测患者血清和胸液异烟肼浓度。结果 :急性结核性胸膜炎患者血清异烟肼浓度为 8.2 6m g/L,胸液异烟肼浓度为 6.63 mg/L;慢性包裹性结核性胸膜炎患者血清异烟肼浓度为 7.73 mg/L,胸液异烟肼浓度为 2 .60 m g/L。结论 :慢性包裹性胸膜炎患者的异烟肼浓度明显低于自身血清和急性结核性胸膜炎患者胸液的异烟肼浓度。因此检测结核性胸膜炎患者血清和胸液异烟肼的浓度对治疗慢性包裹性结核性胸膜炎 。

Objective: To study the effect of concentraction of the drug on treatment of tuberculous pleurisy. Methods: Determination of isonaizid concentration in serum and hydrothorax in patients by HPLC. Result: Isoniazid concentrations of serum and hydrothorax were in 8.26 mg/L and 6.63 mg/L respectively, isoniazid concentrations of serum and hydrothorax were 7.73 mg/L and 2.60 mg/L respectively in patients of chronic sacculated tuberculous pleurisy. Conclusion: Isoniazid concentration in hydrothorax of patients with chronic sacculated pleuritis is marked lower than that in hydrothorax of patients with occur tuberculous pleuritis and in patient himself serum. It is very important in instruction of treating chronic sacculated tuberculous pleuritis, especially in instruction of treating tuberculous pyothorax.