摘要
目的探讨艾司西酞普兰治疗抑郁症有效性和安全性。方法将2013年1月至2015年1月我院诊断为抑郁症的患者100例随机分配2组,每组50例,定义为研究组和对照组,分别给予艾司西酞普兰和西酞普兰。对比研究组和对照组治疗前、治疗2、4周时HAMD分值、治疗前、治疗2、4周时抑郁症的疗效以及两组使用药物的安全性。结果研究组和对照组治疗前汉密尔顿抑郁量表评分结果比较无差异(P>0.05),而治疗4、8周时汉密尔顿抑郁量表评分结果比较有差异(P<0.05)。研究组和对照组治疗前、治疗2、4周时抑郁症的有效率分别为(38%、84%)、(12%、68%),结果比较有差异(P<0.05);研究组和对照组服用药物期间发生不良反应例数分别为5、17例,结果比较有差异(P<0.05)。结论本次研究认为艾司西酞普兰治疗抑郁症的疗效好于西酞普兰,使用安全性好。
Objective To explore the efficacy and safety of Escitalopram treating depression. Methods 100 cases of depression patients were randomly divided into study group and control group, 50 cases each. They respectively received Escitalopram and citalopram. Results The HAMD (Hamilton Depression Scale) scores of study group and control group before treatment showed no difference (P〉0.05), yet 4 weeks and 8 weeks after treatment, HAMD scores of two group had significant difference (P〈0.05). The effective treatment rate of 2 weeks after treatment and 4 weeks after treatment of two groups were respectively (38%, 84%), (12%, 68%). The occurrence number of adverse reactions of two groups were 5 cases and 17 cases (P 〈0.05). Conclusion The study suggests that the efficacy of escitalopram in the treatment of depression is better than citalopram, and it has good security.
出处
《中国医药指南》
2016年第2期16-17,共2页
Guide of China Medicine