线粒体荧光探针最新研究进展

Progress in research of mitochondrial fluorescence probes

细胞器的研究一直是认识细胞结构和功能的重要手段。线粒体是细胞的能量工厂,参与众多的新陈代谢过程,许多病理学过程均与它相关,是一种重要的细胞器,一直以来都是研究的热点。定位于线粒体的荧光探针主要分为3大类,本文重点介绍并讨论近10年基于带有正电荷的荧光团或者在荧光团中引入三苯基膦等定位基团实现对线粒体染色荧光探针的研究进展。

The researches on organelles are important ways to study the structure and function of cells. Mitochondria, the principal energy-producing compartments in most cells, play roles in the numerous vital cellular processes. Thus, the organelles are crucially involved in various pathologies. As one of the most important cellular organelles, mitochondria are always the focus of researches. There are three kinds of mitochondrial fluorescence probes. This paper mainly introduces and discusses the progresses of mitochondrial staining kind of fluorescent probes in recent 10 years on the basis of the fluorophore with positive charge or the introduction of positioning groups such as triphenylphosphine.